InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Hnf4a

Summary

InnateDB Gene

IDBG-211899.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hnf4a

Gene Name

hepatic nuclear factor 4, alpha

Synonyms

HNF-4; Hnf4; Hnf4alpha; MODY1; Nr2a1; Tcf14

Species

Mus musculus

Ensembl Gene

ENSMUSG00000017950

Encoded Proteins

IDBP-211903

hepatic nuclear factor 4, alpha

IDBP-262444

hepatic nuclear factor 4, alpha

IDBP-537332

hepatic nuclear factor 4, alpha

IDBP-536038

hepatic nuclear factor 4, alpha

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101076:
The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms. [provided by RefSeq, Apr 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:163506808-163572910

Strand

Forward strand

Band

Transcripts

ENSMUST00000018094	ENSMUSP00000018094
ENSMUST00000109411	ENSMUSP00000105038
ENSMUST00000143911	ENSMUSP00000119479
ENSMUST00000131658
ENSMUST00000137449	ENSMUSP00000123511

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 1604 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	12 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1604 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0001102	RNA polymerase II activating transcription factor binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005102	receptor binding
GO:0005504	fatty acid binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0042803	protein homodimerization activity
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0006591	ornithine metabolic process
GO:0006629	lipid metabolic process
GO:0006805	xenobiotic metabolic process
GO:0007548	sex differentiation
GO:0007596	blood coagulation
GO:0008285	negative regulation of cell proliferation
GO:0009749	response to glucose
GO:0010470	regulation of gastrulation
GO:0019216	regulation of lipid metabolic process
GO:0023019	signal transduction involved in regulation of gene expression
GO:0030308	negative regulation of cell growth
GO:0030522	intracellular receptor signaling pathway
GO:0031018	endocrine pancreas development
GO:0042593	glucose homeostasis
GO:0043401	steroid hormone mediated signaling pathway
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050796	regulation of insulin secretion
GO:0055088	lipid homeostasis
GO:0055091	phospholipid homeostasis
GO:0060395	SMAD protein signal transduction
GO:0070328	triglyceride homeostasis
GO:2000189	positive regulation of cholesterol homeostasis