Version 5.4
Mus musculus Gene: Nags
Summary
InnateDB Gene IDBG-212463.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nags
Gene Name N-acetylglutamate synthase
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000048217
Encoded Proteins
IDBP-212465
N-acetylglutamate synthase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000161653:
The N-acetylglutamate synthase gene encodes a mitochondrial enzyme that catalyzes the formation of N-acetylglutamate (NAG) from glutamate and acetyl coenzyme-A. NAG is a cofactor of carbamyl phosphate synthetase I (CPSI), the first enzyme of the urea cycle in mammals. This gene may regulate ureagenesis by altering NAG availability and, thereby, CPSI activity. Deficiencies in N-acetylglutamate synthase have been associated with hyperammonemia. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:102145513-102149477
Strand Forward strand
Band D
Transcripts
ENSMUST00000055409 ENSMUSP00000050258
ENSMUST00000129799
ENSMUST00000147252
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004042 acetyl-CoA:L-glutamate N-acetyltransferase activity
GO:0008080 N-acetyltransferase activity
Biological Process
GO:0000050 urea cycle
GO:0006526 arginine biosynthetic process
GO:0006536 glutamate metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000161653
View Gene Order
ENSBTAG00000016249
Not yet available
Pathways
NETPATH
REACTOME
REACT_188937
Metabolism pathway
REACT_246679
Urea cycle pathway
REACT_232845
Metabolism of amino acids and derivatives pathway
KEGG
mmu00330
Arginine and proline metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_847
Urea cycle pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_111217
Metabolism pathway
KEGG
hsa00330
Arginine and proline metabolism pathway
INOH
PID NCI
Cross-References
SwissProt Q8R4H7
TrEMBL
UniProt Splice Variant
Entrez Gene 217214
UniGene Mm.31686
RefSeq NM_145829 NM_178053
OMIM
CCDS CCDS25488
HPRD
IMGT
MGI ID MGI:2387600
MGI Symbol Nags
EMBL AF462069 AJ489814 AK075765 AL591145 BC057990 CH466558
GenPept AAH57990 AAL86770 BAC35941 CAD34015 CAM23258 EDL34091
RNA Seq Atlas 217214

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca