Version 5.4
Mus musculus Gene: Elmo2
Summary
InnateDB Gene IDBG-212599.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Elmo2
Gene Name engulfment and cell motility 2
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000017670
Encoded Proteins
IDBP-212601
engulfment and cell motility 2, ced-12 homolog (C. elegans)
IDBP-212603
engulfment and cell motility 2, ced-12 homolog (C. elegans)
IDBP-212605
engulfment and cell motility 2, ced-12 homolog (C. elegans)
IDBP-212613
engulfment and cell motility 2, ced-12 homolog (C. elegans)
IDBP-212615
engulfment and cell motility 2, ced-12 homolog (C. elegans)
IDBP-536341
engulfment and cell motility 2, ced-12 homolog (C. elegans)
IDBP-539417
engulfment and cell motility 2, ced-12 homolog (C. elegans)
IDBP-534948
engulfment and cell motility 2, ced-12 homolog (C. elegans)
IDBP-539910
engulfment and cell motility 2, ced-12 homolog (C. elegans)
IDBP-534830
engulfment and cell motility 2, ced-12 homolog (C. elegans)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000062598:
The protein encoded by this gene interacts with the dedicator of cyto-kinesis 1 protein. Similarity to a C. elegans protein suggests that this protein may function in phagocytosis of apoptotic cells and in cell migration. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:165288031-165326479
Strand Reverse strand
Band H3
Transcripts
ENSMUST00000074046 ENSMUSP00000073691
ENSMUST00000094329 ENSMUSP00000091887
ENSMUST00000103091 ENSMUSP00000099380
ENSMUST00000103088 ENSMUSP00000099377
ENSMUST00000071699 ENSMUSP00000071619
ENSMUST00000148643 ENSMUSP00000117124
ENSMUST00000127496
ENSMUST00000137188 ENSMUSP00000123232
ENSMUST00000149844
ENSMUST00000126318 ENSMUSP00000116124
ENSMUST00000133205 ENSMUSP00000119682
ENSMUST00000128690 ENSMUSP00000114303
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0017124 SH3 domain binding
GO:0030971 receptor tyrosine kinase binding
Biological Process
GO:0006909 phagocytosis
GO:0006915 apoptotic process
GO:0060326 cell chemotaxis
Cellular Component
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000062598
View Gene Order
ENSBTAG00000003639
Not yet available
Pathways
NETPATH
REACTOME
REACT_239142
Innate Immune System pathway
REACT_198374
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_227951
Signaling by VEGF pathway
REACT_230745
Immune System pathway
REACT_257088
VEGFA-VEGFR2 Pathway pathway
REACT_209368
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_188257
Signal Transduction pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_160086
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_12529
Signaling by VEGF pathway
REACT_6802
Innate Immune System pathway
REACT_111102
Signal Transduction pathway
REACT_6900
Immune System pathway
REACT_228166
VEGFA-VEGFR2 Pathway pathway
REACT_160123
Fcgamma receptor (FCGR) dependent phagocytosis pathway
KEGG
INOH
PID NCI
ilk_pathway
Integrin-linked kinase signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.410913
RefSeq NM_080287 NM_207705 NM_207706 XM_006498740 XM_006498741 XM_006498742 XM_006498743 XM_006498744 XM_006498745
OMIM
CCDS CCDS17075 CCDS17076 CCDS17077
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca