Homo sapiens Gene: ELMO2
Summary
InnateDB Gene IDBG-79125.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ELMO2
Gene Name engulfment and cell motility 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000062598
Encoded Proteins
engulfment and cell motility 2
engulfment and cell motility 2
engulfment and cell motility 2
engulfment and cell motility 2
engulfment and cell motility 2
engulfment and cell motility 2
engulfment and cell motility 2
engulfment and cell motility 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene interacts with the dedicator of cyto-kinesis 1 protein. Similarity to a C. elegans protein suggests that this protein may function in phagocytosis of apoptotic cells and in cell migration. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:46366049-46432985
Strand Reverse strand
Band q13.12
Transcripts
ENST00000372176 ENSP00000361249
ENST00000290246 ENSP00000290246
ENST00000352077 ENSP00000326172
ENST00000396391 ENSP00000379673
ENST00000452857 ENSP00000414329
ENST00000425546 ENSP00000388962
ENST00000450812 ENSP00000416181
ENST00000467800 ENSP00000431972
ENST00000464448
ENST00000462491
ENST00000481852
ENST00000488853
ENST00000480042
ENST00000469801
ENST00000460474
ENST00000497412
ENST00000487583
ENST00000462593
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0017124 SH3 domain binding
GO:0030971 receptor tyrosine kinase binding
Biological Process
GO:0006909 phagocytosis
GO:0006915 apoptotic process
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0045087 innate immune response
GO:0060326 cell chemotaxis
Cellular Component
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
REACTOME
Regulation of actin dynamics for phagocytic cup formation pathway
Signaling by VEGF pathway
Innate Immune System pathway
Signal Transduction pathway
Immune System pathway
VEGFA-VEGFR2 Pathway pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Integrin-linked kinase signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.210469
RefSeq NM_133171 NM_182764 XM_005260496 XM_005260497 XM_005260500 XM_006723854 XM_006723855
HUGO
OMIM
CCDS CCDS13398
HPRD 12103
IMGT
EMBL
GenPept
RNA Seq Atlas