Version 5.4
| Mus musculus Gene: Ins2 | |||||||||||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||||||||||
| InnateDB Gene | IDBG-212636.6 | ||||||||||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||
| Gene Symbol | Ins2 | ||||||||||||||||||||||||||||||
| Gene Name | insulin II | ||||||||||||||||||||||||||||||
| Synonyms | AA986540; Ins-2; InsII; Mody; Mody4; proinsulin | ||||||||||||||||||||||||||||||
| Species | Mus musculus | ||||||||||||||||||||||||||||||
| Ensembl Gene | ENSMUSG00000000215 | ||||||||||||||||||||||||||||||
| Encoded Proteins |
insulin II
insulin II
insulin II
insulin II
insulin II
insulin II
insulin II
insulin II
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| Protein Structure | |||||||||||||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000254647:
After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010] After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5\' region and with the IGF2 gene at the 3\' region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010] |
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| Gene Information | |||||||||||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||||||||||
| Genomic Location | Chromosome 7:142678656-142699510 | ||||||||||||||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||||||||||||||
| Band | F5 | ||||||||||||||||||||||||||||||
| Transcripts | |||||||||||||||||||||||||||||||
| Interactions | |||||||||||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||||||||||
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Species
Homo sapiens
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Gene ID
Gene Order
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| Pathways | |||||||||||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||||||||||
| REACTOME |
SHC activation pathway
Disease pathway
SHC-related events pathway
Signaling by Insulin receptor pathway
Integration of energy metabolism pathway
Amyloids pathway
Signal attenuation pathway
Metabolism pathway
Metabolism of proteins pathway
Regulation of insulin secretion pathway
Peptide hormone metabolism pathway
Insulin receptor signalling cascade pathway
Synthesis, secretion, and deacylation of Ghrelin pathway
IRS activation pathway
IRS-related events pathway
Insulin receptor recycling pathway
Signal Transduction pathway
Insulin processing pathway
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| KEGG |
Maturity onset diabetes of the young pathway
Type I diabetes mellitus pathway
Type II diabetes mellitus pathway
Regulation of autophagy pathway
Insulin signaling pathway pathway
Regulation of actin cytoskeleton pathway
mTOR signaling pathway pathway
Prostate cancer pathway
Progesterone-mediated oocyte maturation pathway
Aldosterone-regulated sodium reabsorption pathway
Oocyte meiosis pathway
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| INOH |
Insulin receptor signaling pathway
GPCR signaling pathway
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| PID NCI | |||||||||||||||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||||||||||
| REACTOME |
Insulin receptor recycling pathway
Signal attenuation pathway
IRS activation pathway
SHC activation pathway
Signaling by Insulin receptor pathway
Insulin processing pathway
Synthesis, secretion, and deacylation of Ghrelin pathway
Regulation of insulin secretion pathway
Integration of energy metabolism pathway
Regulation of gene expression in beta cells pathway
SHC-related events pathway
Developmental Biology pathway
Regulation of beta-cell development pathway
Signal Transduction pathway
Metabolism of proteins pathway
Insulin receptor signalling cascade pathway
IRS-related events pathway
Metabolism pathway
Peptide hormone metabolism pathway
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| KEGG |
Regulation of actin cytoskeleton pathway
mTOR signaling pathway pathway
Regulation of autophagy pathway
Type I diabetes mellitus pathway
Insulin signaling pathway pathway
Prostate cancer pathway
Maturity onset diabetes of the young pathway
Type II diabetes mellitus pathway
Progesterone-mediated oocyte maturation pathway
Aldosterone-regulated sodium reabsorption pathway
Oocyte meiosis pathway
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| INOH |
Insulin receptor signaling pathway
GPCR signaling pathway
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| PID NCI |
FOXA2 and FOXA3 transcription factor networks
Signaling events mediated by PTP1B
ATF-2 transcription factor network
Signaling events mediated by TCPTP
FOXA1 transcription factor network
Arf6 trafficking events
Insulin Pathway
Insulin-mediated glucose transport
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| Cross-References | |||||||||||||||||||||||||||||||
| SwissProt | |||||||||||||||||||||||||||||||
| TrEMBL | |||||||||||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||||||||||
| UniGene | |||||||||||||||||||||||||||||||
| RefSeq | NM_001185083 NM_001185084 NM_008387 | ||||||||||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||||||||||
| CCDS | CCDS22034 | ||||||||||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||||||||||
| MGI ID | |||||||||||||||||||||||||||||||
| MGI Symbol | |||||||||||||||||||||||||||||||
| EMBL | |||||||||||||||||||||||||||||||
| GenPept | |||||||||||||||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||||||||||||||