Homo sapiens Gene: INS
Summary
InnateDB Gene IDBG-547491.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol INS
Gene Name insulin
Synonyms IDDM1; IDDM2; ILPR; IRDN; MODY10;
Species Homo sapiens
Ensembl Gene ENSG00000254647
Encoded Proteins
insulin
insulin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]
After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5\' region and with the IGF2 gene at the 3\' region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:2159779-2161341
Strand Reverse strand
Band p15.5
Transcripts
ENST00000381330 ENSP00000370731
ENST00000250971 ENSP00000250971
ENST00000397262 ENSP00000380432
ENST00000421783 ENSP00000408400
ENST00000512523 ENSP00000424008
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0002020 protease binding
GO:0005158 insulin receptor binding
GO:0005159 insulin-like growth factor receptor binding
GO:0005179 hormone activity
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0000165 MAPK cascade
GO:0002674 negative regulation of acute inflammatory response
GO:0006006 glucose metabolic process
GO:0006112 energy reserve metabolic process
GO:0006355 regulation of transcription, DNA-templated
GO:0006521 regulation of cellular amino acid metabolic process
GO:0006953 acute-phase response
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007267 cell-cell signaling
GO:0008284 positive regulation of cell proliferation
GO:0008286 insulin receptor signaling pathway
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0015758 glucose transport
GO:0022898 regulation of transmembrane transporter activity
GO:0030307 positive regulation of cell growth
GO:0030335 positive regulation of cell migration
GO:0031018 endocrine pancreas development
GO:0031954 positive regulation of protein autophosphorylation
GO:0032148 activation of protein kinase B activity
GO:0032270 positive regulation of cellular protein metabolic process
GO:0032460 negative regulation of protein oligomerization
GO:0032880 regulation of protein localization
GO:0033861 negative regulation of NAD(P)H oxidase activity
GO:0042060 wound healing
GO:0042177 negative regulation of protein catabolic process
GO:0042593 glucose homeostasis
GO:0043410 positive regulation of MAPK cascade
GO:0044267 cellular protein metabolic process
GO:0044281 small molecule metabolic process
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045597 positive regulation of cell differentiation
GO:0045721 negative regulation of gluconeogenesis
GO:0045725 positive regulation of glycogen biosynthetic process
GO:0045740 positive regulation of DNA replication
GO:0045818 negative regulation of glycogen catabolic process
GO:0045821 positive regulation of glycolytic process
GO:0045840 positive regulation of mitosis
GO:0045861 negative regulation of proteolysis
GO:0045908 negative regulation of vasodilation
GO:0045909 positive regulation of vasodilation
GO:0045922 negative regulation of fatty acid metabolic process
GO:0046326 positive regulation of glucose import
GO:0046628 positive regulation of insulin receptor signaling pathway
GO:0046631 alpha-beta T cell activation
GO:0046889 positive regulation of lipid biosynthetic process
GO:0050708 regulation of protein secretion
GO:0050709 negative regulation of protein secretion
GO:0050715 positive regulation of cytokine secretion
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050796 regulation of insulin secretion
GO:0050995 negative regulation of lipid catabolic process
GO:0051000 positive regulation of nitric-oxide synthase activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051897 positive regulation of protein kinase B signaling
GO:0055089 fatty acid homeostasis
GO:0060266 negative regulation of respiratory burst involved in inflammatory response
GO:0060267 positive regulation of respiratory burst
GO:0090277 positive regulation of peptide hormone secretion
GO:0090336 positive regulation of brown fat cell differentiation
GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:2000252 negative regulation of feeding behavior
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005788 endoplasmic reticulum lumen
GO:0005796 Golgi lumen
GO:0031904 endosome lumen
GO:0034774 secretory granule lumen
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
Integration of energy metabolism pathway
SHC-related events pathway
Developmental Biology pathway
Regulation of beta-cell development pathway
SHC activation pathway
Insulin receptor recycling pathway
Signal Transduction pathway
Metabolism of proteins pathway
Regulation of gene expression in beta cells pathway
Insulin receptor signalling cascade pathway
IRS-related events pathway
Insulin processing pathway
IRS activation pathway
Signal attenuation pathway
Regulation of insulin secretion pathway
Synthesis, secretion, and deacylation of Ghrelin pathway
Signaling by Insulin receptor pathway
Metabolism pathway
Peptide hormone metabolism pathway
KEGG
Oocyte meiosis pathway
Regulation of autophagy pathway
mTOR signaling pathway pathway
Regulation of actin cytoskeleton pathway
Insulin signaling pathway pathway
Progesterone-mediated oocyte maturation pathway
Type II diabetes mellitus pathway
Type I diabetes mellitus pathway
Maturity onset diabetes of the young pathway
Aldosterone-regulated sodium reabsorption pathway
Prostate cancer pathway
INOH
GPCR signaling pathway
Insulin receptor signaling pathway
PID BIOCARTA
PID NCI
FOXA2 and FOXA3 transcription factor networks
Signaling events mediated by PTP1B
ATF-2 transcription factor network
Signaling events mediated by TCPTP
FOXA1 transcription factor network
Arf6 trafficking events
Insulin Pathway
Insulin-mediated glucose transport
Cross-References
SwissProt P01308
TrEMBL A6XGL2 C9JNR5 F6MZK5 I3WAC9
UniProt Splice Variant
Entrez Gene 3630
UniGene Hs.698284 Hs.704133
RefSeq NM_000207 NM_001185097 NM_001185098
HUGO HGNC:6081
OMIM 176730
CCDS CCDS7729
HPRD
IMGT
EMBL AC132217 AJ009655 AY138590 AY899304 BC005255 BT006808 CH471158 DQ778082 J00265 JF909299 JQ951950 L15440 M10039 V00565 X70508
GenPept AAA59172 AAA59173 AAA59179 AAH05255 AAN39451 AAP35454 AAW83741 ABI63346 AEG19452 AFK93533 CAA08766 CAA23828 CAA49913 EAX02488 EAX02489
RNA Seq Atlas 3630