InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Sulf2

Summary

InnateDB Gene

IDBG-212851.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sulf2

Gene Name

sulfatase 2

Synonyms

2010004N24Rik; AU020235; mKIAA1247; MSulf-2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000006800

Encoded Proteins

IDBP-212853

sulfatase 2

IDBP-262793

sulfatase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196562:
Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005 [PubMed 16192265]).[supplied by OMIM, Mar 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:166073089-166155663

Strand

Reverse strand

Band

Transcripts

ENSMUST00000088086	ENSMUSP00000085405
ENSMUST00000109249	ENSMUSP00000104872
ENSMUST00000146497
ENSMUST00000125503
ENSMUST00000143996
ENSMUST00000139266
ENSMUST00000133395

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004065	arylsulfatase activity
GO:0005509	calcium ion binding
GO:0008449	N-acetylglucosamine-6-sulfatase activity
GO:0008484	sulfuric ester hydrolase activity

Biological Process

GO:0001822	kidney development
GO:0002063	chondrocyte development
GO:0003094	glomerular filtration
GO:0006790	sulfur compound metabolic process
GO:0008152	metabolic process
GO:0010575	positive regulation vascular endothelial growth factor production
GO:0014846	esophagus smooth muscle contraction
GO:0030177	positive regulation of Wnt signaling pathway
GO:0030201	heparan sulfate proteoglycan metabolic process
GO:0032836	glomerular basement membrane development
GO:0035860	glial cell-derived neurotrophic factor receptor signaling pathway
GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway
GO:0048706	embryonic skeletal system development
GO:0051216	cartilage development
GO:0060348	bone development
GO:0060384	innervation

Cellular Component

GO:0005615	extracellular space
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005795	Golgi stack
GO:0005886	plasma membrane
GO:0009986	cell surface

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000196562

View Gene Order

ENSBTAG00000007490

Not yet available

Cross-References

SwissProt

Q8CFG0

TrEMBL

UniProt Splice Variant

Entrez Gene

72043

UniGene

Mm.1011 Mm.465746

RefSeq

NM_001252578 NM_001252579 NM_028072 XM_006500208 XM_006500209 XM_006500210 XM_006500211

OMIM

CCDS

CCDS17086

HPRD

IMGT

MGI ID

MGI:1919293

MGI Symbol

Sulf2

EMBL

AK008108 AK028874 AK034712 AK036685 AK049170 AK081643 AK133336 AK165183 AL589873 AY101177 BC027238 BC141086

GenPept

AAH27238 AAI41087 AAM76862 BAB25464 BAC26165 BAC28804 BAC29534 BAC33584 BAC38279 BAE21607 BAE38065 CAM13978

RNA Seq Atlas

72043