Version 5.4
Homo sapiens Gene: SULF2
Summary
InnateDB Gene IDBG-79894.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SULF2
Gene Name sulfatase 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000196562
Encoded Proteins
IDBP-79896
sulfatase 2
IDBP-377887
sulfatase 2
IDBP-478537
sulfatase 2
IDBP-474154
sulfatase 2
IDBP-478945
sulfatase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005 [PubMed 16192265]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:47656348-47786616
Strand Reverse strand
Band q13.12
Transcripts
ENST00000359930 ENSP00000353007
ENST00000433632
ENST00000437955 ENSP00000410026
ENST00000479472
ENST00000479970
ENST00000484875 ENSP00000418290
ENST00000495544 ENSP00000417894
ENST00000467815 ENSP00000418442
ENST00000465769
ENST00000474450
ENST00000463221
ENST00000478766
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004065 arylsulfatase activity
GO:0005509 calcium ion binding
GO:0008449 N-acetylglucosamine-6-sulfatase activity
GO:0008484 sulfuric ester hydrolase activity
Biological Process
GO:0001822 kidney development
GO:0002063 chondrocyte development
GO:0003094 glomerular filtration
GO:0008152 metabolic process
GO:0010575 positive regulation vascular endothelial growth factor production
GO:0014846 esophagus smooth muscle contraction
GO:0030177 positive regulation of Wnt signaling pathway
GO:0030201 heparan sulfate proteoglycan metabolic process
GO:0032836 glomerular basement membrane development
GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway
GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway
GO:0048706 embryonic skeletal system development
GO:0051216 cartilage development
GO:0060348 bone development
GO:0060384 innervation
Cellular Component
GO:0005615 extracellular space
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005795 Golgi stack
GO:0005886 plasma membrane
GO:0009986 cell surface
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000006800
View Gene Order
ENSBTAG00000007490
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.162016 Hs.668626
RefSeq NM_001161841 NM_018837 NM_198596 XM_005260458 XM_006723827 XM_006723828 XM_006723829 XM_006723830
HUGO
OMIM
CCDS CCDS13408 CCDS13409
HPRD 18130
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca