Mus musculus Gene: Kcnb1
Summary
InnateDB Gene IDBG-213015.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Kcnb1
Gene Name potassium voltage gated channel, Shab-related subfamily, member 1
Synonyms Kcr1-1; Kv2.1; Shab;
Species Mus musculus
Ensembl Gene ENSMUSG00000050556
Encoded Proteins
potassium voltage gated channel, Shab-related subfamily, member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000158445:
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel and its activity is modulated by some other family members. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:167103378-167190155
Strand Reverse strand
Band H3
Transcripts
ENSMUST00000059826 ENSMUSP00000057981
ENSMUST00000131267
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005249 voltage-gated potassium channel activity
GO:0005251 delayed rectifier potassium channel activity
GO:0005515 protein binding
GO:0015271 outward rectifier potassium channel activity
GO:0047485 protein N-terminus binding
Biological Process
GO:0006811 ion transport
GO:0006813 potassium ion transport
GO:0034765 regulation of ion transmembrane transport
GO:0051259 protein oligomerization
GO:0051260 protein homooligomerization
GO:0055085 transmembrane transport
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0008076 voltage-gated potassium channel complex
GO:0016020 membrane
GO:0030425 dendrite
GO:0032590 dendrite membrane
GO:0032809 neuronal cell body membrane
GO:0043025 neuronal cell body
GO:0045211 postsynaptic membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Integration of energy metabolism pathway
Metabolism pathway
Regulation of insulin secretion pathway
Potassium Channels pathway
Neuronal System pathway
Voltage gated Potassium channels pathway
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway
KEGG
Taste transduction pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Integration of energy metabolism pathway
Neuronal System pathway
Voltage gated Potassium channels pathway
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway
Potassium Channels pathway
Regulation of insulin secretion pathway
Metabolism pathway
KEGG
Taste transduction pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q03717
TrEMBL Q0N2S5
UniProt Splice Variant
Entrez Gene 16500
UniGene Mm.205341 Mm.471100
RefSeq NM_008420
OMIM
CCDS CCDS17096
HPRD
IMGT
MGI ID MGI:96666
MGI Symbol Kcnb1
EMBL AL591711 AL591854 BC031776 BC061501 CH466551 DQ646376 DQ646377 M64228
GenPept AAA40112 AAH31776 AAH61501 ABI14792 ABI14793 CAM13429 CAM17304 EDL06500
RNA Seq Atlas 16500