Version 5.4
Mus musculus Gene: Cdc27
Summary
InnateDB Gene IDBG-213149.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cdc27
Gene Name cell division cycle 27
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000020687
Encoded Proteins
IDBP-213151
cell division cycle 27 homolog (S. cerevisiae)
IDBP-267667
cell division cycle 27 homolog (S. cerevisiae)
IDBP-267669
cell division cycle 27 homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000004897:
The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eucaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and thus may be involved in controlling the timing of mitosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:104502745-104550620
Strand Reverse strand
Band E1
Transcripts
ENSMUST00000093923 ENSMUSP00000091452
ENSMUST00000106962 ENSMUSP00000102575
ENSMUST00000106961 ENSMUSP00000102574
ENSMUST00000127506
ENSMUST00000135303
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 93 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 93 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019903 protein phosphatase binding
Biological Process
GO:0007091 metaphase/anaphase transition of mitotic cell cycle
GO:0051301 cell division
GO:0070979 protein K11-linked ubiquitination
Cellular Component
GO:0005634 nucleus
GO:0005680 anaphase-promoting complex
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005876 spindle microtubule
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000004897
View Gene Order
ENSBTAG00000002726
Not yet available
Pathways
NETPATH
REACTOME
REACT_215601
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase pathway
REACT_249770
Cell Cycle, Mitotic pathway
REACT_236645
Class I MHC mediated antigen processing & presentation pathway
REACT_222875
APC/C:Cdc20 mediated degradation of mitotic proteins pathway
REACT_207679
Separation of Sister Chromatids pathway
REACT_188957
Cellular responses to stress pathway
REACT_222604
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins pathway
REACT_188804
Cell Cycle pathway
REACT_244364
APC/C-mediated degradation of cell cycle proteins pathway
REACT_230745
Immune System pathway
REACT_241408
M Phase pathway
REACT_256025
Cell Cycle Checkpoints pathway
REACT_199115
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_188820
Cellular Senescence pathway
REACT_246476
Regulation of APC/C activators between G1/S and early anaphase pathway
REACT_226135
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway
REACT_225686
Autodegradation of Cdh1 by Cdh1:APC/C pathway
REACT_254995
Regulation of mitotic cell cycle pathway
REACT_219897
APC/C:Cdc20 mediated degradation of Securin pathway
REACT_199403
Mitotic Metaphase and Anaphase pathway
REACT_205250
Phosphorylation of the APC/C pathway
REACT_206033
Senescence-Associated Secretory Phenotype (SASP) pathway
REACT_248037
Inactivation of APC/C via direct inhibition of the APC/C complex pathway
REACT_229531
Adaptive Immune System pathway
REACT_234036
Mitotic Spindle Checkpoint pathway
REACT_202512
Mitotic Anaphase pathway
REACT_263475
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components pathway
REACT_210462
APC/C:Cdc20 mediated degradation of Cyclin B pathway
KEGG
mmu04120
Ubiquitin mediated proteolysis pathway
mmu04110
Cell cycle pathway
mmu04914
Progesterone-mediated oocyte maturation pathway
mmu04114
Oocyte meiosis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_7
TGF_beta_Receptor pathway
REACTOME
REACT_1072
Inactivation of APC/C via direct inhibition of the APC/C complex pathway
REACT_1041
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components pathway
REACT_6761
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway
REACT_6820
APC/C:Cdc20 mediated degradation of Cyclin B pathway
REACT_6871
APC/C:Cdc20 mediated degradation of Securin pathway
REACT_6781
APC/C:Cdc20 mediated degradation of mitotic proteins pathway
REACT_6904
Phosphorylation of the APC/C pathway
REACT_6785
Autodegradation of Cdh1 by Cdh1:APC/C pathway
REACT_6867
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase pathway
REACT_6837
Regulation of APC/C activators between G1/S and early anaphase pathway
REACT_150471
Separation of Sister Chromatids pathway
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_120956
Cellular responses to stress pathway
REACT_6828
APC/C-mediated degradation of cell cycle proteins pathway
REACT_6954
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins pathway
REACT_21279
Regulation of mitotic cell cycle pathway
REACT_115566
Cell Cycle pathway
REACT_75774
Adaptive Immune System pathway
REACT_2137
Mitotic Spindle Checkpoint pathway
REACT_6900
Immune System pathway
REACT_910
M Phase pathway
REACT_169274
Cellular Senescence pathway
REACT_1275
Mitotic Anaphase pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_169168
Senescence-Associated Secretory Phenotype (SASP) pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
REACT_1538
Cell Cycle Checkpoints pathway
REACT_150314
Mitotic Metaphase and Anaphase pathway
REACT_213075
Regulation of APC/C activators between G1/S and early anaphase pathway
REACT_216366
M Phase pathway
REACT_216181
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins pathway
REACT_212887
Separation of Sister Chromatids pathway
REACT_206069
Cellular responses to stress pathway
REACT_215084
Mitotic Metaphase and Anaphase pathway
REACT_211185
Mitotic Anaphase pathway
REACT_222622
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway
REACT_215505
Cell Cycle, Mitotic pathway
REACT_209611
Phosphorylation of the APC/C pathway
REACT_214934
Cell Cycle pathway
REACT_215025
Cellular Senescence pathway
REACT_202159
Mitotic Spindle Checkpoint pathway
REACT_202818
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components pathway
REACT_218686
APC/C:Cdc20 mediated degradation of Cyclin B pathway
REACT_212154
Regulation of mitotic cell cycle pathway
REACT_218054
APC/C-mediated degradation of cell cycle proteins pathway
REACT_218125
Inactivation of APC/C via direct inhibition of the APC/C complex pathway
REACT_220866
APC/C:Cdc20 mediated degradation of mitotic proteins pathway
REACT_203215
Senescence-Associated Secretory Phenotype (SASP) pathway
REACT_224819
Cell Cycle Checkpoints pathway
REACT_208116
Autodegradation of Cdh1 by Cdh1:APC/C pathway
REACT_204829
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase pathway
REACT_205339
APC/C:Cdc20 mediated degradation of Securin pathway
KEGG
hsa04110
Cell cycle pathway
hsa04120
Ubiquitin mediated proteolysis pathway
hsa04914
Progesterone-mediated oocyte maturation pathway
hsa04114
Oocyte meiosis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.470268 Mm.472819 Mm.473561 Mm.89845
RefSeq NM_001285988 NM_001285989 NM_145436 XM_006533050 XM_006533051 XM_006533052
OMIM
CCDS CCDS36354
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca