Homo sapiens Gene: CDC27
Summary
InnateDB Gene IDBG-55802.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDC27
Gene Name cell division cycle 27 homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000004897
Encoded Proteins
cell division cycle 27 homolog (S. cerevisiae)
cell division cycle 27 homolog (S. cerevisiae)
cell division cycle 27 homolog (S. cerevisiae)
cell division cycle 27 homolog (S. cerevisiae)
cell division cycle 27 homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eucaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and thus may be involved in controlling the timing of mitosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:47117703-47189422
Strand Reverse strand
Band q21.32
Transcripts
ENST00000066544 ENSP00000066544
ENST00000525495
ENST00000531206 ENSP00000434614
ENST00000533415 ENSP00000432211
ENST00000527547 ENSP00000437339
ENST00000526866 ENSP00000432105
ENST00000532893 ENSP00000466424
ENST00000528748
ENST00000532575
ENST00000528147
ENST00000576484 ENSP00000459307
ENST00000570740 ENSP00000460830
ENST00000575830
ENST00000574304 ENSP00000458904
ENST00000571643 ENSP00000460279
ENST00000575483 ENSP00000460454
ENST00000573502 ENSP00000460132
ENST00000573550 ENSP00000460424
ENST00000570818 ENSP00000460061
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 161 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 161 [view]
Protein-Protein 160 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019903 protein phosphatase binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0007091 metaphase/anaphase transition of mitotic cell cycle
GO:0007094 mitotic spindle assembly checkpoint
GO:0008283 cell proliferation
GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0051301 cell division
GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0070979 protein K11-linked ubiquitination
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005680 anaphase-promoting complex
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005819 spindle
GO:0005829 cytosol
GO:0005876 spindle microtubule
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
TGF_beta_Receptor pathway
REACTOME
Cellular responses to stress pathway
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase pathway
APC/C-mediated degradation of cell cycle proteins pathway
APC/C:Cdc20 mediated degradation of Cyclin B pathway
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins pathway
Regulation of mitotic cell cycle pathway
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components pathway
APC/C:Cdc20 mediated degradation of Securin pathway
Regulation of APC/C activators between G1/S and early anaphase pathway
Autodegradation of Cdh1 by Cdh1:APC/C pathway
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway
Inactivation of APC/C via direct inhibition of the APC/C complex pathway
Separation of Sister Chromatids pathway
Cell Cycle pathway
Adaptive Immune System pathway
Mitotic Spindle Checkpoint pathway
Immune System pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
M Phase pathway
Cellular Senescence pathway
Mitotic Anaphase pathway
Cell Cycle, Mitotic pathway
Senescence-Associated Secretory Phenotype (SASP) pathway
Class I MHC mediated antigen processing & presentation pathway
APC/C:Cdc20 mediated degradation of mitotic proteins pathway
Phosphorylation of the APC/C pathway
Cell Cycle Checkpoints pathway
Mitotic Metaphase and Anaphase pathway
KEGG
Cell cycle pathway
Oocyte meiosis pathway
Ubiquitin mediated proteolysis pathway
Progesterone-mediated oocyte maturation pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL K7EMA6
UniProt Splice Variant
Entrez Gene 996
UniGene Hs.463295 Hs.574664 Hs.597011 Hs.602766 Hs.734423
RefSeq NM_001256 NM_001293091 NM_001114091 NM_001293089 XM_006722221 XM_006722220 XM_006722219 XM_005257892
HUGO HGNC:1728
OMIM 116946
CCDS CCDS11509 CCDS45720 CCDS74090
HPRD 00304
IMGT
EMBL AC002558
GenPept
RNA Seq Atlas 996