InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CDC27

Summary

InnateDB Gene

IDBG-55802.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDC27

Gene Name

cell division cycle 27 homolog (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000004897

Encoded Proteins

IDBP-55804

cell division cycle 27 homolog (S. cerevisiae)

IDBP-598822

cell division cycle 27 homolog (S. cerevisiae)

IDBP-590056

cell division cycle 27 homolog (S. cerevisiae)

IDBP-586329

cell division cycle 27 homolog (S. cerevisiae)

IDBP-585893

cell division cycle 27 homolog (S. cerevisiae)

IDBP-763938

IDBP-757827

IDBP-761049

IDBP-764422

IDBP-763250

IDBP-760984

IDBP-758202

IDBP-759793

IDBP-761782

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eucaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and thus may be involved in controlling the timing of mitosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:47117703-47189422

Strand

Reverse strand

Band

q21.32

Transcripts

ENST00000066544	ENSP00000066544
ENST00000525495
ENST00000531206	ENSP00000434614
ENST00000533415	ENSP00000432211
ENST00000527547	ENSP00000437339
ENST00000526866	ENSP00000432105
ENST00000532893	ENSP00000466424
ENST00000528748
ENST00000532575
ENST00000528147
ENST00000576484	ENSP00000459307
ENST00000570740	ENSP00000460830
ENST00000575830
ENST00000574304	ENSP00000458904
ENST00000571643	ENSP00000460279
ENST00000575483	ENSP00000460454
ENST00000573502	ENSP00000460132
ENST00000573550	ENSP00000460424
ENST00000570818	ENSP00000460061

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 161 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	161 [view]
Protein-Protein	160 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019903	protein phosphatase binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0007091	metaphase/anaphase transition of mitotic cell cycle
GO:0007094	mitotic spindle assembly checkpoint
GO:0008283	cell proliferation
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0051301	cell division
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0070979	protein K11-linked ubiquitination

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005680	anaphase-promoting complex
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005819	spindle
GO:0005829	cytosol
GO:0005876	spindle microtubule