Mus musculus Gene: Map3k3 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-213345.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Map3k3 | ||||||||||||||||||||||
Gene Name | mitogen-activated protein kinase kinase kinase 3 | ||||||||||||||||||||||
Synonyms | AW548911; MAPKKK3; Mekk3; mKIAA4031 | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000020700 | ||||||||||||||||||||||
Encoded Proteins |
mitogen-activated protein kinase kinase kinase 3
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
InnateDB Annotation from Orthologs | |||||||||||||||||||||||
Summary |
[Homo sapiens] MAP3K3 in its unphosphorylated form can form a complex with unphosphorylated MAP3K7 (TAK1) where non-phosphorylated MAP3K7 interferes with MAP3K3 phosphorylation and NF-kappaB reporter activity.
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Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198909:
This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] This gene product is a 626-amino acid polypeptide that is 96.5%% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 11:106084613-106155446 | ||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||
Band | E1 | ||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 163 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Cytokine Signaling in Immune system pathway
Immune System pathway
Signaling by Interleukins pathway
Interleukin-1 signaling pathway
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KEGG |
GnRH signaling pathway pathway
MAPK signaling pathway pathway
Neurotrophin signaling pathway pathway
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INOH |
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
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PID NCI | |||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH |
EGFR1 pathway
TNFalpha pathway
IL1 pathway
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REACTOME |
Interleukin-1 signaling pathway
Cytokine Signaling in Immune system pathway
Immune System pathway
Signaling by Interleukins pathway
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KEGG |
GnRH signaling pathway pathway
MAPK signaling pathway pathway
Neurotrophin signaling pathway pathway
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INOH |
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
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PID NCI |
IL1-mediated signaling events
TNF receptor signaling pathway
Regulation of p38-alpha and p38-beta
p38 MAPK signaling pathway
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Cross-References | |||||||||||||||||||||||
SwissProt | Q61084 | ||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 26406 | ||||||||||||||||||||||
UniGene | |||||||||||||||||||||||
RefSeq | NM_011947 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS25548 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
MGI ID | MGI:1346874 | ||||||||||||||||||||||
MGI Symbol | Map3k3 | ||||||||||||||||||||||
EMBL | BC023781 U43187 | ||||||||||||||||||||||
GenPept | AAB03535 AAH23781 | ||||||||||||||||||||||
RNA Seq Atlas | 26406 | ||||||||||||||||||||||