InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MAP3K3

Summary

InnateDB Gene

IDBG-63432.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAP3K3

Gene Name

mitogen-activated protein kinase kinase kinase 3

Synonyms

MAPKKK3; MEKK3

Species

Homo sapiens

Ensembl Gene

ENSG00000198909

Encoded Proteins

IDBP-63434

mitogen-activated protein kinase kinase kinase 3

IDBP-63436

mitogen-activated protein kinase kinase kinase 3

IDBP-762483

IDBP-761361

IDBP-762561

IDBP-758156

IDBP-763876

IDBP-763878

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 18206350

MAP3K3 in its unphosphorylated form can form a complex with unphosphorylated MAP3K7 (TAK1) where non-phosphorylated MAP3K7 interferes with MAP3K3 phosphorylation and NF-kappaB reporter activity.

Entrez Gene

Summary

This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
This gene product is a 626-amino acid polypeptide that is 96.5%% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:63622415-63696303

Strand

Forward strand

Band

q23.3

Transcripts

ENST00000361357	ENSP00000354927
ENST00000361733	ENSP00000354485
ENST00000577597	ENSP00000462917
ENST00000585302	ENSP00000464532
ENST00000577784
ENST00000579585	ENSP00000461988
ENST00000578622
ENST00000577839
ENST00000581732	ENSP00000464482
ENST00000584573	ENSP00000464130
ENST00000577395	ENSP00000462086

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 81 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	81 [view]
Protein-Protein	80 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004709	MAP kinase kinase kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0046872	metal ion binding

Biological Process

GO:0000165	MAPK cascade
GO:0000186	activation of MAPKK activity
GO:0006468	protein phosphorylation
GO:0035556	intracellular signal transduction
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087	innate immune response (InnateDB)
GO:0046777	protein autophosphorylation