Version 5.4
Homo sapiens Gene: CDC42BPB
Summary
InnateDB Gene IDBG-21367.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDC42BPB
Gene Name CDC42 binding protein kinase beta (DMPK-like)
Synonyms MRCKB
Species Homo sapiens
Ensembl Gene ENSG00000198752
Encoded Proteins
IDBP-21369
CDC42 binding protein kinase beta (DMPK-like)
IDBP-600046
CDC42 binding protein kinase beta (DMPK-like)
IDBP-586884
CDC42 binding protein kinase beta (DMPK-like)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the serine/threonine protein kinase family. The encoded protein contains a Cdc42/Rac-binding p21 binding domain resembling that of PAK kinase. The kinase domain of this protein is most closely related to that of myotonic dystrophy kinase-related ROK. Studies of the similar gene in rat suggested that this kinase may act as a downstream effector of Cdc42 in cytoskeletal reorganization. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:102932379-103057462
Strand Reverse strand
Band q32.32
Transcripts
ENST00000361246 ENSP00000355237
ENST00000560492
ENST00000559790
ENST00000559245
ENST00000558867 ENSP00000453311
ENST00000559043 ENSP00000453384
ENST00000558321
ENST00000561271
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 11 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005083 small GTPase regulator activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0017048 Rho GTPase binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007010 cytoskeleton organization
GO:0007163 establishment or maintenance of cell polarity
GO:0007165 signal transduction
GO:0016477 cell migration
GO:0030036 actin cytoskeleton organization
GO:0031032 actomyosin structure organization
GO:0031532 actin cytoskeleton reorganization
GO:0035556 intracellular signal transduction
GO:0050790 regulation of catalytic activity
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0031252 cell leading edge
GO:0042641 actomyosin
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021279
View Gene Order
ENSBTAG00000016456
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.654634 Hs.699815 Hs.709485
RefSeq NM_006035
HUGO
OMIM
CCDS CCDS9978
HPRD 08516
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca