Homo sapiens Gene: CDC42BPB
Summary
InnateDB Gene IDBG-21367.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDC42BPB
Gene Name CDC42 binding protein kinase beta (DMPK-like)
Synonyms MRCKB;
Species Homo sapiens
Ensembl Gene ENSG00000198752
Encoded Proteins
CDC42 binding protein kinase beta (DMPK-like)
CDC42 binding protein kinase beta (DMPK-like)
CDC42 binding protein kinase beta (DMPK-like)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the serine/threonine protein kinase family. The encoded protein contains a Cdc42/Rac-binding p21 binding domain resembling that of PAK kinase. The kinase domain of this protein is most closely related to that of myotonic dystrophy kinase-related ROK. Studies of the similar gene in rat suggested that this kinase may act as a downstream effector of Cdc42 in cytoskeletal reorganization. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:102932379-103057462
Strand Reverse strand
Band q32.32
Transcripts
ENST00000361246 ENSP00000355237
ENST00000560492
ENST00000559790
ENST00000559245
ENST00000558867 ENSP00000453311
ENST00000559043 ENSP00000453384
ENST00000558321
ENST00000561271
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 11 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005083 small GTPase regulator activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0017048 Rho GTPase binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007010 cytoskeleton organization
GO:0007163 establishment or maintenance of cell polarity
GO:0007165 signal transduction
GO:0016477 cell migration
GO:0030036 actin cytoskeleton organization
GO:0031032 actomyosin structure organization
GO:0031532 actin cytoskeleton reorganization
GO:0035556 intracellular signal transduction
GO:0050790 regulation of catalytic activity
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0031252 cell leading edge
GO:0042641 actomyosin
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.654634 Hs.699815 Hs.709485
RefSeq NM_006035
HUGO
OMIM
CCDS CCDS9978
HPRD 08516
IMGT
EMBL
GenPept
RNA Seq Atlas