Version 5.4
Mus musculus Gene: Apoh
Summary
InnateDB Gene IDBG-213761.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Apoh
Gene Name apolipoprotein H
Synonyms B2GPI; beta-2-GPI; beta2-GPI
Species Mus musculus
Ensembl Gene ENSMUSG00000000049
Encoded Proteins
IDBP-213763
apolipoprotein H
IDBP-538705
apolipoprotein H
IDBP-532766
apolipoprotein H
IDBP-540050
apolipoprotein H
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21965665
Apoh is a plasma protein that specifically interacts with lipopolysaccharide (LPS) and Tlr4 to induce Tnf-alpha production in macrophages. (Demonstrated in human)
InnateDB Annotation from Orthologs
Summary
PMID 21965665
[Homo sapiens] APOH is a plasma protein that specifically interacts with lipopolysaccharide (LPS) and TLR4 to induce TNF-alpha production in macrophages.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000091583:
Apolipoprotein H has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome, but it does not seem to be required for the reactivity of antiphospholipid autoantibodies associated with infections. [provided by RefSeq, Jul 2008]
Apolipoprotein H has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome, but it does not seem to be required for the reactivity of antiphospholipid autoantibodies associated with infections. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:108343354-108414396
Strand Forward strand
Band E1
Transcripts
ENSMUST00000000049 ENSMUSP00000000049
ENSMUST00000133383 ENSMUSP00000115516
ENSMUST00000146050 ENSMUSP00000123486
ENSMUST00000152958 ENSMUSP00000114214
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001948 glycoprotein binding
GO:0005515 protein binding
GO:0005543 phospholipid binding
GO:0008201 heparin binding
GO:0008289 lipid binding
GO:0042802 identical protein binding
GO:0060230 lipoprotein lipase activator activity
Biological Process
GO:0001937 negative regulation of endothelial cell proliferation
GO:0006641 triglyceride metabolic process
GO:0007597 blood coagulation, intrinsic pathway
GO:0010596 negative regulation of endothelial cell migration
GO:0016525 negative regulation of angiogenesis
GO:0030193 regulation of blood coagulation
GO:0030195 negative regulation of blood coagulation
GO:0031639 plasminogen activation
GO:0033033 negative regulation of myeloid cell apoptotic process
GO:0034392 negative regulation of smooth muscle cell apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0051006 positive regulation of lipoprotein lipase activity
GO:0051917 regulation of fibrinolysis
GO:0051918 negative regulation of fibrinolysis
Cellular Component
GO:0005615 extracellular space
GO:0009986 cell surface
GO:0031012 extracellular matrix
GO:0034361 very-low-density lipoprotein particle
GO:0034364 high-density lipoprotein particle
GO:0042627 chylomicron
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000091583
View Gene Order
ENSBTAG00000001915
Not yet available
Cross-References
SwissProt Q01339
TrEMBL I7HJR3 I7HPW5 J3JS85 Q6LAL7
UniProt Splice Variant
Entrez Gene 11818
UniGene Mm.487984
RefSeq NM_013475 XM_006532042
OMIM
CCDS CCDS25574
HPRD
IMGT
MGI ID MGI:88058
MGI Symbol Apoh
EMBL AL607041 AL935172 BC019811 BC053338 D10056 S70439 Y08224 Y08225 Y08226 Y08227 Y08228 Y08229 Y08230 Y11356
GenPept AAB30789 AAH19811 AAH53338 BAA00945 CAA69401 CAA72190
RNA Seq Atlas 11818

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca