InnateDB Protein
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IDBP-213763.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Apoh
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Protein Name
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apolipoprotein H
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Synonyms
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B2GPI; beta-2-GPI; beta2-GPI;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000000049
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InnateDB Gene
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IDBG-213761 (Apoh)
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Protein Structure
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Function |
Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.
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Subcellular Localization |
Secreted.
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Disease Associations |
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Tissue Specificity |
Expressed by the liver and secreted in plasma.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
14 [view]
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Molecular Function |
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Biological Process |
GO:0001937
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negative regulation of endothelial cell proliferation
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GO:0006641
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triglyceride metabolic process
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GO:0007597
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blood coagulation, intrinsic pathway
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GO:0010596
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negative regulation of endothelial cell migration
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GO:0016525
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negative regulation of angiogenesis
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GO:0030193
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regulation of blood coagulation
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GO:0030195
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negative regulation of blood coagulation
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GO:0031639
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plasminogen activation
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GO:0033033
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negative regulation of myeloid cell apoptotic process
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GO:0034392
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negative regulation of smooth muscle cell apoptotic process
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GO:0045087
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innate immune response (InnateDB)
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GO:0051006
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positive regulation of lipoprotein lipase activity
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GO:0051917
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regulation of fibrinolysis
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GO:0051918
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negative regulation of fibrinolysis
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Cellular Component |
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PDB ID |
MGI:88058
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InterPro |
IPR000436
Sushi/SCR/CCP
IPR015104
Beta-2-glycoprotein-1 fifth domain
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PFAM |
PF00084
PF09014
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PRINTS |
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PIRSF |
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SMART |
SM00032
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TIGRFAMs |
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Modification |
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SwissProt |
Q01339
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PhosphoSite |
PhosphoSite-Q01339
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TrEMBL |
Q6LAL7
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UniProt Splice Variant |
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Entrez Gene |
11818
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UniGene |
Mm.487984
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RefSeq |
NP_038503
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MGI ID |
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MGI Symbol |
Apoh
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OMIM |
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CCDS |
CCDS25574
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HPRD |
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IMGT |
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EMBL |
AL607041
AL935172
BC019811
BC053338
D10056
S70439
Y08224
Y08225
Y08226
Y08227
Y08228
Y08229
Y08230
Y11356
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GenPept |
AAB30789
AAH19811
AAH53338
BAA00945
CAA69401
CAA72190
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