InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Abca8b

Summary

InnateDB Gene

IDBG-213870.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Abca8b

Gene Name

ATP-binding cassette, sub-family A (ABC1), member 8b

Synonyms

Abca8

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020620

Encoded Proteins

IDBP-213872

ATP-binding cassette, sub-family A (ABC1), member 8b

IDBP-268288

ATP-binding cassette, sub-family A (ABC1), member 8b

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000141338:
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. The function of this protein has not yet been determined. [provided by RefSeq, Jul 2008]
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. The encoded protein may regulate lipid metabolism and be involved in the formation and maintenance of myelin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:109932190-109995845

Strand

Reverse strand

Band

Transcripts

ENSMUST00000020948	ENSMUSP00000020948
ENSMUST00000106669	ENSMUSP00000102280

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005524	ATP binding
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity
GO:0042626	ATPase activity, coupled to transmembrane movement of substances

Biological Process

GO:0006200	ATP catabolic process
GO:0006810	transport
GO:0055085	transmembrane transport

Cellular Component

GO:0005743	mitochondrial inner membrane
GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Orthologs

Species

Homo sapiens

Gene ID

Gene Order

ENSG00000141338

View Gene Order

Pathways

NETPATH

REACTOME

REACT_253400

Transmembrane transport of small molecules pathway

REACT_237882

ABC-family proteins mediated transport pathway

KEGG

mmu02010

ABC transporters pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_15480

ABC-family proteins mediated transport pathway

REACT_15518

Transmembrane transport of small molecules pathway

KEGG

hsa02010

ABC transporters pathway

INOH

PID NCI

Cross-References

SwissProt

Q8K440

TrEMBL

A2AM56

UniProt Splice Variant

Entrez Gene

27404

UniGene

Mm.341004

RefSeq

NM_013851 XM_006533459 XM_006533461 XM_006533464 XM_006533462 XM_006533463

OMIM

CCDS

CCDS25587

HPRD

IMGT

MGI ID

MGI:1351668

MGI Symbol

Abca8b

EMBL

AF213393 AF498362 AK043744 AK173034 AL807245 BC141401

GenPept

AAF31432 AAI41402 AAM90908 BAC31640 BAD32312 CAM13339

RNA Seq Atlas

27404