InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ABCA8

Summary

InnateDB Gene

IDBG-65993.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ABCA8

Gene Name

ATP-binding cassette, sub-family A (ABC1), member 8

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000141338

Encoded Proteins

IDBP-65997

ATP-binding cassette, sub-family A (ABC1), member 8

IDBP-383742

ATP-binding cassette, sub-family A (ABC1), member 8

IDBP-761813

IDBP-758877

IDBP-760310

IDBP-809441

ATP-binding cassette, sub-family A (ABC1), member 8

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. The function of this protein has not yet been determined. [provided by RefSeq, Jul 2008]
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. The encoded protein may regulate lipid metabolism and be involved in the formation and maintenance of myelin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:68867292-68955392

Strand

Reverse strand

Band

q24.2

Transcripts

ENST00000269080	ENSP00000269080
ENST00000428549
ENST00000430352	ENSP00000402814
ENST00000541225
ENST00000586539	ENSP00000467271
ENST00000590359
ENST00000585531	ENSP00000466126
ENST00000591459
ENST00000586292
ENST00000589980
ENST00000588458
ENST00000589533	ENSP00000467186
ENST00000585850
ENST00000587206
ENST00000615593	ENSP00000481467

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005524	ATP binding
GO:0005525	GTP binding
GO:0016887	ATPase activity
GO:0042626	ATPase activity, coupled to transmembrane movement of substances

Biological Process

GO:0006200	ATP catabolic process
GO:0006810	transport
GO:0055085	transmembrane transport

Cellular Component

GO:0005743	mitochondrial inner membrane
GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Orthologs

Species

Mus musculus

Gene ID

Gene Order

ENSMUSG00000020620

View Gene Order

Pathways

NETPATH

REACTOME

REACT_15480

ABC-family proteins mediated transport pathway

REACT_15518

Transmembrane transport of small molecules pathway

KEGG

hsa02010

ABC transporters pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.58351 Hs.606204

RefSeq

NM_001288985 NM_001288986 NM_007168 XM_005256938 XM_005256940

HUGO

OMIM

CCDS

CCDS11680 CCDS74138 CCDS74139

HPRD

09790

IMGT

EMBL

GenPept

RNA Seq Atlas