Version 5.4
Homo sapiens Gene: MARK3
Summary
InnateDB Gene IDBG-21538.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MARK3
Gene Name MAP/microtubule affinity-regulating kinase 3
Synonyms CTAK1; KP78; Par-1a; PAR1A
Species Homo sapiens
Ensembl Gene ENSG00000075413
Encoded Proteins
IDBP-21540
MAP/microtubule affinity-regulating kinase 3
IDBP-21542
MAP/microtubule affinity-regulating kinase 3
IDBP-21546
MAP/microtubule affinity-regulating kinase 3
IDBP-378020
MAP/microtubule affinity-regulating kinase 3
IDBP-378022
MAP/microtubule affinity-regulating kinase 3
IDBP-378024
MAP/microtubule affinity-regulating kinase 3
IDBP-583753
MAP/microtubule affinity-regulating kinase 3
IDBP-585761
MAP/microtubule affinity-regulating kinase 3
IDBP-589012
MAP/microtubule affinity-regulating kinase 3
IDBP-589096
MAP/microtubule affinity-regulating kinase 3
IDBP-583432
MAP/microtubule affinity-regulating kinase 3
IDBP-601964
MAP/microtubule affinity-regulating kinase 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is activated by phosphorylation and in turn is involved in the phosphorylation of tau proteins MAP2 and MAP4. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:103385392-103503831
Strand Forward strand
Band q32.32
Transcripts
ENST00000303622 ENSP00000303698
ENST00000335102 ENSP00000335347
ENST00000216288 ENSP00000216288
ENST00000429436 ENSP00000411397
ENST00000416682 ENSP00000408092
ENST00000440884 ENSP00000402104
ENST00000559328
ENST00000560603
ENST00000553942 ENSP00000450772
ENST00000560417 ENSP00000454169
ENST00000558223
ENST00000561225 ENSP00000452829
ENST00000561071
ENST00000558698
ENST00000560731
ENST00000559268
ENST00000561164
ENST00000554627 ENSP00000450460
ENST00000558953
ENST00000558611
ENST00000559274
ENST00000561314 ENSP00000452893
ENST00000556744 ENSP00000451623
ENST00000556463
ENST00000558787
ENST00000555235
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 54 [view]
Protein-Protein 54 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006468 protein phosphorylation
GO:0016310 phosphorylation
Cellular Component
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000007411
View Gene Order
ENSBTAG00000013410
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.35828 Hs.611669 Hs.688742
RefSeq NM_001128918 NM_001128919 NM_001128920 NM_001128921 NM_002376 XM_006720146 XM_006720147
HUGO
OMIM
CCDS CCDS41993 CCDS45165 CCDS45166 CCDS45167 CCDS55947
HPRD 04058
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca