InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TNFSF9

Summary

InnateDB Gene

IDBG-21688.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNFSF9

Gene Name

tumor necrosis factor (ligand) superfamily, member 9

Synonyms

4-1BB-L; CD137L

Species

Homo sapiens

Ensembl Gene

ENSG00000125657

Encoded Proteins

IDBP-21690

tumor necrosis factor (ligand) superfamily, member 9

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21747409

The expression of ligand-receptor pair TNFSF9-TNFRSF9 on monocytes and NK cells is induced by Mycobacterium tuberculosis. Blockage of the TNFRSF9 pathway enhanced the level of IFNG and TNFA producing lymphocytes against the pathogen.

Entrez Gene

Summary

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.[provided by RefSeq, Oct 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:6530999-6535928

Strand

Forward strand

Band

p13.3

Transcripts

ENST00000245817

ENSP00000245817

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005125	cytokine activity
GO:0005164	tumor necrosis factor receptor binding
GO:0005515	protein binding
GO:0032813	tumor necrosis factor receptor superfamily binding

Biological Process

GO:0006915	apoptotic process
GO:0006955	immune response
GO:0007165	signal transduction
GO:0007267	cell-cell signaling
GO:0008283	cell proliferation
GO:0032729	positive regulation of interferon-gamma production
GO:0032735	positive regulation of interleukin-12 production
GO:0032755	positive regulation of interleukin-6 production
GO:0042104	positive regulation of activated T cell proliferation
GO:0042127	regulation of cell proliferation
GO:0043011	myeloid dendritic cell differentiation
GO:0045087	innate immune response (InnateDB)
GO:0045585	positive regulation of cytotoxic T cell differentiation

Cellular Component

GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Orthologs

No orthologs found for this gene

Pathways

NETPATH

REACTOME

KEGG

hsa04060

Cytokine-cytokine receptor interaction pathway

INOH

PID NCI

Cross-References

SwissProt

P41273

TrEMBL

UniProt Splice Variant

Entrez Gene

8744

UniGene

Hs.1524

RefSeq

NM_003811 XM_006722931

HUGO

HGNC:11939

OMIM

606182

CCDS

CCDS12169

HPRD

IMGT

EMBL

BC104805 BC104807 U03398

GenPept

AAA53134 AAI04806 AAI04808

RNA Seq Atlas

8744