Homo sapiens Gene: TNFSF9
Summary
InnateDB Gene IDBG-21688.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNFSF9
Gene Name tumor necrosis factor (ligand) superfamily, member 9
Synonyms 4-1BB-L; CD137L;
Species Homo sapiens
Ensembl Gene ENSG00000125657
Encoded Proteins
tumor necrosis factor (ligand) superfamily, member 9
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
The expression of ligand-receptor pair TNFSF9-TNFRSF9 on monocytes and NK cells is induced by Mycobacterium tuberculosis. Blockage of the TNFRSF9 pathway enhanced the level of IFNG and TNFA producing lymphocytes against the pathogen.
Entrez Gene
Summary The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.[provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:6530999-6535928
Strand Forward strand
Band p13.3
Transcripts
ENST00000245817 ENSP00000245817
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005125 cytokine activity
GO:0005164 tumor necrosis factor receptor binding
GO:0005515 protein binding
GO:0032813 tumor necrosis factor receptor superfamily binding
Biological Process
GO:0006915 apoptotic process
GO:0006955 immune response
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0008283 cell proliferation
GO:0032729 positive regulation of interferon-gamma production
GO:0032735 positive regulation of interleukin-12 production
GO:0032755 positive regulation of interleukin-6 production
GO:0042104 positive regulation of activated T cell proliferation
GO:0042127 regulation of cell proliferation
GO:0043011 myeloid dendritic cell differentiation
GO:0045087 innate immune response (InnateDB)
GO:0045585 positive regulation of cytotoxic T cell differentiation
Cellular Component
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
Cytokine-cytokine receptor interaction pathway
INOH
PID BIOCARTA
The 41bb-dependent immune response [Biocarta view]
PID NCI
Cross-References
SwissProt P41273
TrEMBL
UniProt Splice Variant
Entrez Gene 8744
UniGene Hs.1524
RefSeq NM_003811 XM_006722931
HUGO HGNC:11939
OMIM 606182
CCDS CCDS12169
HPRD 05861
IMGT
EMBL BC104805 BC104807 U03398
GenPept AAA53134 AAI04806 AAI04808
RNA Seq Atlas 8744