|Homo sapiens Gene: TNFSF9|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||tumor necrosis factor (ligand) superfamily, member 9|
tumor necrosis factor (ligand) superfamily, member 9
|Useful resources||Stemformatics EHFPI ImmGen|
The expression of ligand-receptor pair TNFSF9-TNFRSF9 on monocytes and NK cells is induced by Mycobacterium tuberculosis. Blockage of the TNFRSF9 pathway enhanced the level of IFNG and TNFA producing lymphocytes against the pathogen.
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.[provided by RefSeq, Oct 2008]
|Genomic Location||Chromosome 19:6530999-6535928|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
|No orthologs found for this gene|
Cytokine-cytokine receptor interaction pathway
|UniProt Splice Variant|
|EMBL||BC104805 BC104807 U03398|
|GenPept||AAA53134 AAI04806 AAI04808|
|RNA Seq Atlas||8744|