Homo sapiens Gene: STRA6
Summary
InnateDB Gene IDBG-21876.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol STRA6
Gene Name stimulated by retinoic acid 6 homolog (mouse)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000137868
Encoded Proteins
stimulated by retinoic acid gene 6 homolog (mouse)
stimulated by retinoic acid gene 6 homolog (mouse)
stimulated by retinoic acid gene 6 homolog (mouse)
stimulated by retinoic acid gene 6 homolog (mouse)
stimulated by retinoic acid gene 6 homolog (mouse)
stimulated by retinoic acid gene 6 homolog (mouse)
stimulated by retinoic acid gene 6 homolog (mouse)
stimulated by retinoic acid 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a membrane protein involved in the metabolism of retinol. The encoded protein acts as a receptor for retinol/retinol binding protein complexes. This protein removes the retinol from the complex and transports it across the cell membrane. Defects in this gene are a cause of syndromic microphthalmia type 9 (MCOPS9). Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:74179466-74212267
Strand Reverse strand
Band q24.1
Transcripts
ENST00000323940 ENSP00000326085
ENST00000395105 ENSP00000378537
ENST00000423167 ENSP00000413012
ENST00000416286 ENSP00000400403
ENST00000449139 ENSP00000410221
ENST00000432245 ENSP00000407176
ENST00000535552 ENSP00000440238
ENST00000545137
ENST00000573724
ENST00000574278 ENSP00000458827
ENST00000573214
ENST00000575272
ENST00000571341 ENSP00000458204
ENST00000572975
ENST00000572785 ENSP00000459546
ENST00000573456
ENST00000569936 ENSP00000461799
ENST00000574439
ENST00000563965 ENSP00000456609
ENST00000574570
ENST00000573391 ENSP00000458734
ENST00000616000 ENSP00000479112
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0051183 vitamin transporter activity
Biological Process
GO:0001523 retinoid metabolic process
GO:0001568 blood vessel development
GO:0001822 kidney development
GO:0003184 pulmonary valve morphogenesis
GO:0003281 ventricular septum development
GO:0007507 heart development
GO:0007603 phototransduction, visible light
GO:0007612 learning
GO:0007631 feeding behavior
GO:0030324 lung development
GO:0030325 adrenal gland development
GO:0030540 female genitalia development
GO:0034633 retinol transport
GO:0042297 vocal learning
GO:0042573 retinoic acid metabolic process
GO:0043583 ear development
GO:0043585 nose morphogenesis
GO:0046427 positive regulation of JAK-STAT cascade
GO:0048286 lung alveolus development
GO:0048520 positive regulation of behavior
GO:0048546 digestive tract morphogenesis
GO:0048566 embryonic digestive tract development
GO:0048589 developmental growth
GO:0048745 smooth muscle tissue development
GO:0048844 artery morphogenesis
GO:0050890 cognition
GO:0050905 neuromuscular process
GO:0051180 vitamin transport
GO:0060322 head development
GO:0060323 head morphogenesis
GO:0060325 face morphogenesis
GO:0060426 lung vasculature development
GO:0060539 diaphragm development
GO:0060900 embryonic camera-type eye formation
GO:0061029 eyelid development in camera-type eye
GO:0061038 uterus morphogenesis
GO:0061143 alveolar primary septum development
GO:0061156 pulmonary artery morphogenesis
GO:0061205 paramesonephric duct development
GO:0071939 vitamin A import
GO:0097070 ductus arteriosus closure
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
The canonical retinoid cycle in rods (twilight vision) pathway
Signal Transduction pathway
Diseases associated with visual transduction pathway
Visual phototransduction pathway
Retinoid cycle disease events pathway
Disease pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9BX79
TrEMBL I3L0M6
UniProt Splice Variant
Entrez Gene 64220
UniGene Hs.24553
RefSeq NM_001142620 NM_001142617 NM_001142618 NM_001142619 NM_001199040 NM_001199041 NM_001199042 NM_022369
HUGO HGNC:30650
OMIM 610745
CCDS CCDS45302 CCDS10261 CCDS45301 CCDS55973 CCDS55974 CCDS58387
HPRD 18122
IMGT
EMBL AC023545 AF352728 AF352729 AF370419 AK022603 AK291966 AK299191 AK302932 AY358748 AY359089 BC015881 BC025256 BX537413 CH471136
GenPept AAH15881 AAH25256 AAK30289 AAK30290 AAQ15255 AAQ89108 AAQ89447 BAB14122 BAF84655 BAH12965 BAH13848 CAD97655 EAW99353 EAW99356
RNA Seq Atlas 64220