Version 5.4
Homo sapiens Gene: NSMAF
Summary
InnateDB Gene IDBG-22729.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NSMAF
Gene Name neutral sphingomyelinase (N-SMase) activation associated factor
Synonyms FAN
Species Homo sapiens
Ensembl Gene ENSG00000035681
Encoded Proteins
IDBP-22731
neutral sphingomyelinase (N-SMase) activation associated factor
IDBP-371166
neutral sphingomyelinase (N-SMase) activation associated factor
IDBP-476529
neutral sphingomyelinase (N-SMase) activation associated factor
IDBP-478501
neutral sphingomyelinase (N-SMase) activation associated factor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a WD-repeat protein that binds the cytoplasmic sphingomyelinase activation domain of the 55kD tumor necrosis factor receptor. This protein is required for TNF-mediated activation of neutral sphingomyelinase and may play a role in regulating TNF-induced cellular responses such as inflammation. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:58583504-58659844
Strand Reverse strand
Band q12.1
Transcripts
ENST00000038176 ENSP00000038176
ENST00000427130 ENSP00000411012
ENST00000521972
ENST00000517612
ENST00000521712
ENST00000523177
ENST00000519166
ENST00000524148
ENST00000523106
ENST00000519174
ENST00000523982
ENST00000519227
ENST00000519858
ENST00000518229 ENSP00000430195
ENST00000518159 ENSP00000430982
ENST00000522645
ENST00000519871
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005057 receptor signaling protein activity
GO:0005515 protein binding
GO:0016230 sphingomyelin phosphodiesterase activator activity
Biological Process
GO:0006672 ceramide metabolic process
GO:0007165 signal transduction
GO:0035556 intracellular signal transduction
GO:0043065 positive regulation of apoptotic process
GO:0043085 positive regulation of catalytic activity
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028245
View Gene Order
ENSBTAG00000008958
Not yet available
Pathways
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
KEGG
INOH
PID NCI
tnfpathway
TNF receptor signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.372000
RefSeq NM_001144772 NM_003580
HUGO
OMIM
CCDS CCDS47864 CCDS6173
HPRD 09117
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca