Homo sapiens Gene: COX5A
Summary
InnateDB Gene IDBG-22937.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol COX5A
Gene Name cytochrome c oxidase subunit Va
Synonyms COX; COX-VA; VA;
Species Homo sapiens
Ensembl Gene ENSG00000178741
Encoded Proteins
cytochrome c oxidase subunit Va
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer of proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit Va of the human mitochondrial respiratory chain enzyme. A pseudogene COX5AP1 has been found in chromosome 14q22. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:74919791-74938168
Strand Reverse strand
Band q24.2
Transcripts
ENST00000322347 ENSP00000317780
ENST00000567270 ENSP00000457974
ENST00000568517 ENSP00000456314
ENST00000562233 ENSP00000456253
ENST00000564811 ENSP00000456386
ENST00000568783 ENSP00000455053
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004129 cytochrome-c oxidase activity
GO:0009055 electron carrier activity
GO:0046872 metal ion binding
Biological Process
GO:0022904 respiratory electron transport chain
GO:0044237 cellular metabolic process
GO:0044281 small molecule metabolic process
GO:1902600 hydrogen ion transmembrane transport
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. pathway
Orphan transporters pathway
The citric acid (TCA) cycle and respiratory electron transport pathway
Metabolism pathway
Respiratory electron transport pathway
KEGG
Oxidative phosphorylation pathway
Cardiac muscle contraction pathway
Alzheimer's disease pathway
Parkinson's disease pathway
Huntington's disease pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL H3BRM5 H3BV69 Q71UP1
UniProt Splice Variant
Entrez Gene 9377
UniGene Hs.574158 Hs.612964 Hs.732727
RefSeq NM_004255
HUGO HGNC:2267
OMIM 603773
CCDS CCDS10273
HPRD 04799
IMGT
EMBL AC125435 AF067635
GenPept AAC73060
RNA Seq Atlas 9377