Version 5.4
Homo sapiens Gene: GYS2
Summary
InnateDB Gene IDBG-22956.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GYS2
Gene Name glycogen synthase 2 (liver)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000111713
Encoded Proteins
IDBP-22958
glycogen synthase 2 (liver)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene, liver glycogen synthase, catalyzes the rate-limiting step in the synthesis of glycogen - the transfer of a glucose molecule from UDP-glucose to a terminal branch of the glycogen molecule. Mutations in this gene cause glycogen storage disease type 0 (GSD-0) - a rare type of early childhood fasting hypoglycemia with decreased liver glycogen content. [provided by RefSeq, Dec 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:21536189-21604847
Strand Reverse strand
Band p12.1
Transcripts
ENST00000261195 ENSP00000261195
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004373 glycogen (starch) synthase activity
GO:0042803 protein homodimerization activity
GO:0061547 glycogen synthase activity, transferring glucose-1-phosphate
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0005978 glycogen biosynthetic process
GO:0006006 glucose metabolic process
GO:0006091 generation of precursor metabolites and energy
GO:0009058 biosynthetic process
GO:0009749 response to glucose
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005938 cell cortex
GO:0030864 cortical actin cytoskeleton
GO:0043265 ectoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030244
View Gene Order
ENSBTAG00000013333
Not yet available
Pathways
NETPATH
REACTOME
REACT_200783
Myoclonic epilepsy of Lafora pathway
REACT_169208
Glycogen synthesis pathway
REACT_474
Metabolism of carbohydrates pathway
REACT_111217
Metabolism pathway
REACT_116125
Disease pathway
REACT_723
Glucose metabolism pathway
REACT_200833
Glycogen storage diseases pathway
KEGG
hsa04910
Insulin signaling pathway pathway
hsa00500
Starch and sucrose metabolism pathway
INOH
INOH website
Insulin receptor signaling pathway
PID NCI
Cross-References
SwissProt P54840
TrEMBL
UniProt Splice Variant
Entrez Gene 2998
UniGene Hs.82614
RefSeq NM_021957 XM_005253352 XM_005253354 XM_006719062 XM_006719063
HUGO HGNC:4707
OMIM 138571
CCDS CCDS8690
HPRD
IMGT
EMBL AC006559 AC010197 AC022072 AJ003087 AJ003088 AJ003089 AJ003090 AJ003091 AJ003092 AJ003093 AJ003094 AJ003095 AJ003096 AJ003097 AJ003098 AJ003099 AJ003100 AJ003101 AJ003102 BC126310 BC126312 D29685 S70004
GenPept AAB30886 AAI26311 AAI26313 BAA06154 CAA05859
RNA Seq Atlas 2998

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca