Homo sapiens Gene: PEX26
Summary
InnateDB Gene IDBG-229866.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PEX26
Gene Name peroxisomal biogenesis factor 26
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000215193
Encoded Proteins
peroxisomal biogenesis factor 26
peroxisomal biogenesis factor 26
peroxisomal biogenesis factor 26
peroxisomal biogenesis factor 26
peroxisomal biogenesis factor 26
peroxisomal biogenesis factor 26
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene belongs to the peroxin-26 gene family. It is probably required for protein import into peroxisomes. It anchors PEX1 and PEX6 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Defects in this gene are the cause of peroxisome biogenesis disorder complementation group 8 (PBD-CG8). PBD refers to a group of peroxisomal disorders arising from a failure of protein import into the peroxisomal membrane or matrix. The PBD group is comprised of four disorders: Zellweger syndrome (ZWS), neonatal adrenoleukodystrophy (NALD), infantile Refsum disease (IRD), and classical rhizomelic chondrodysplasia punctata (RCDP). Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:18077920-18131138
Strand Forward strand
Band q11.21
Transcripts
ENST00000329627 ENSP00000331106
ENST00000399744 ENSP00000382648
ENST00000428061 ENSP00000412441
ENST00000474897 ENSP00000434235
ENST00000610387 ENSP00000482091
ENST00000618979 ENSP00000483492
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 8 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0032403 protein complex binding
GO:0051117 ATPase binding
Biological Process
GO:0016558 protein import into peroxisome matrix
GO:0045046 protein import into peroxisome membrane
Cellular Component
GO:0005777 peroxisome
GO:0005779 integral component of peroxisomal membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Peroxisome pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL E9PRC5
UniProt Splice Variant
Entrez Gene 55670
UniGene Hs.517400
RefSeq NM_001127649 NM_001199319 NM_017929
HUGO HGNC:22965
OMIM 608666
CCDS CCDS13750 CCDS56221
HPRD 10559
IMGT
EMBL AC008079 AC016027
GenPept
RNA Seq Atlas 55670