Homo sapiens Gene: PPCDC
Summary
InnateDB Gene IDBG-23007.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPCDC
Gene Name phosphopantothenoylcysteine decarboxylase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000138621
Encoded Proteins
phosphopantothenoylcysteine decarboxylase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Biosynthesis of coenzyme A (CoA) from pantothenic acid (vitamin B5) is an essential universal pathway in prokaryotes and eukaryotes. PPCDC (EC 4.1.1.36), one of the last enzymes in this pathway, converts phosphopantothenoylcysteine to 4-prime-phosphopantetheine (Daugherty et al., 2002 [PubMed 11923312]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:75023555-75117462
Strand Forward strand
Band q24.2
Transcripts
ENST00000342932 ENSP00000343190
ENST00000564923 ENSP00000456665
ENST00000563298
ENST00000563393 ENSP00000457490
ENST00000567336 ENSP00000456353
ENST00000568649 ENSP00000455691
ENST00000568207
ENST00000562095 ENSP00000457446
ENST00000564953
ENST00000562192
ENST00000569562 ENSP00000455499
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004633 phosphopantothenoylcysteine decarboxylase activity
Biological Process
GO:0006766 vitamin metabolic process
GO:0006767 water-soluble vitamin metabolic process
GO:0008152 metabolic process
GO:0009108 coenzyme biosynthetic process
GO:0015937 coenzyme A biosynthetic process
GO:0015939 pantothenate metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Defective HLCS causes multiple carboxylase deficiency pathway
Defective MUT causes methylmalonic aciduria mut type pathway
Defective MMAA causes methylmalonic aciduria type cblA pathway
Defective TCN2 causes hereditary megaloblastic anemia pathway
Metabolism of water-soluble vitamins and cofactors pathway
Defective AMN causes hereditary megaloblastic anemia 1 pathway
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG pathway
Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF pathway
Coenzyme A biosynthesis pathway
Defective CD320 causes methylmalonic aciduria pathway
Defects in cobalamin (B12) metabolism pathway
Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC pathway
Defects in biotin (Btn) metabolism pathway
Defective BTD causes biotidinase deficiency pathway
Defective GIF causes intrinsic factor deficiency pathway
Vitamin B5 (pantothenate) metabolism pathway
Defects in vitamin and cofactor metabolism pathway
Defective CUBN causes hereditary megaloblastic anemia 1 pathway
Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD pathway
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE pathway
Metabolism pathway
Defective MMAB causes methylmalonic aciduria type cblB pathway
Disease pathway
Metabolism of vitamins and cofactors pathway
KEGG
Pantothenate and CoA biosynthesis pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL H3BPW5 H3BSE3 H3BU63
UniProt Splice Variant
Entrez Gene 60490
UniGene Hs.458922 Hs.640486
RefSeq NM_001301103 XM_006720631 NM_021823 NM_001301105 NM_001301104 NM_001301101 NM_001301102 XM_006720630 XM_005254579
HUGO HGNC:28107
OMIM 609854
CCDS CCDS73761 CCDS10275 CCDS73759 CCDS73760
HPRD 14377
IMGT
EMBL AC015720 AC113208 CH471136
GenPept EAW99275
RNA Seq Atlas 60490