Homo sapiens Gene: PPCDC | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-23007.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | PPCDC | ||||||||||||||||||||||
Gene Name | phosphopantothenoylcysteine decarboxylase | ||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Gene | ENSG00000138621 | ||||||||||||||||||||||
Encoded Proteins |
phosphopantothenoylcysteine decarboxylase
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
Biosynthesis of coenzyme A (CoA) from pantothenic acid (vitamin B5) is an essential universal pathway in prokaryotes and eukaryotes. PPCDC (EC 4.1.1.36), one of the last enzymes in this pathway, converts phosphopantothenoylcysteine to 4-prime-phosphopantetheine (Daugherty et al., 2002 [PubMed 11923312]).[supplied by OMIM, Mar 2008] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 15:75023555-75117462 | ||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||
Band | q24.2 | ||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Method
Confidence
Comments
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Defective HLCS causes multiple carboxylase deficiency pathway
Defective MUT causes methylmalonic aciduria mut type pathway
Defective MMAA causes methylmalonic aciduria type cblA pathway
Defective TCN2 causes hereditary megaloblastic anemia pathway
Metabolism of water-soluble vitamins and cofactors pathway
Defective AMN causes hereditary megaloblastic anemia 1 pathway
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG pathway
Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF pathway
Coenzyme A biosynthesis pathway
Defective CD320 causes methylmalonic aciduria pathway
Defects in cobalamin (B12) metabolism pathway
Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC pathway
Defects in biotin (Btn) metabolism pathway
Defective BTD causes biotidinase deficiency pathway
Defective GIF causes intrinsic factor deficiency pathway
Vitamin B5 (pantothenate) metabolism pathway
Defects in vitamin and cofactor metabolism pathway
Defective CUBN causes hereditary megaloblastic anemia 1 pathway
Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD pathway
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE pathway
Metabolism pathway
Defective MMAB causes methylmalonic aciduria type cblB pathway
Disease pathway
Metabolism of vitamins and cofactors pathway
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KEGG |
Pantothenate and CoA biosynthesis pathway
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INOH | |||||||||||||||||||||||
PID BIOCARTA | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | H3BPW5 H3BSE3 H3BU63 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 60490 | ||||||||||||||||||||||
UniGene | Hs.458922 Hs.640486 | ||||||||||||||||||||||
RefSeq | NM_001301103 XM_006720631 NM_021823 NM_001301105 NM_001301104 NM_001301101 NM_001301102 XM_006720630 XM_005254579 | ||||||||||||||||||||||
HUGO | HGNC:28107 | ||||||||||||||||||||||
OMIM | 609854 | ||||||||||||||||||||||
CCDS | CCDS73761 CCDS10275 CCDS73759 CCDS73760 | ||||||||||||||||||||||
HPRD | 14377 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AC015720 AC113208 CH471136 | ||||||||||||||||||||||
GenPept | EAW99275 | ||||||||||||||||||||||
RNA Seq Atlas | 60490 | ||||||||||||||||||||||