Version 5.4
Homo sapiens Gene: ABCC9
Summary
InnateDB Gene IDBG-23107.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ABCC9
Gene Name ATP-binding cassette, sub-family C (CFTR/MRP), member 9
Synonyms ABC37; ATFB12; CANTU; CMD1O; SUR2
Species Homo sapiens
Ensembl Gene ENSG00000069431
Encoded Proteins
IDBP-23109
ATP-binding cassette, sub-family C (CFTR/MRP), member 9
IDBP-23111
ATP-binding cassette, sub-family C (CFTR/MRP), member 9
IDBP-23115
ATP-binding cassette, sub-family C (CFTR/MRP), member 9
IDBP-601657
ATP-binding cassette, sub-family C (CFTR/MRP), member 9
IDBP-587160
ATP-binding cassette, sub-family C (CFTR/MRP), member 9
IDBP-806846
ATP-binding cassette, sub-family C (CFTR/MRP), member 9
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is thought to form ATP-sensitive potassium channels in cardiac, skeletal, and vascular and non-vascular smooth muscle. Protein structure suggests a role as the drug-binding channel-modulating subunit of the extra-pancreatic ATP-sensitive potassium channels. Mutations in this gene are associated with cardiomyopathy dilated type 1O. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:21797401-21941402
Strand Reverse strand
Band p12.1
Transcripts
ENST00000261200 ENSP00000261200
ENST00000261201 ENSP00000261201
ENST00000326684 ENSP00000317518
ENST00000544039 ENSP00000440521
ENST00000538350 ENSP00000442604
ENST00000621589 ENSP00000480233
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005267 potassium channel activity
GO:0005524 ATP binding
GO:0008281 sulfonylurea receptor activity
GO:0015459 potassium channel regulator activity
GO:0016887 ATPase activity
GO:0042626 ATPase activity, coupled to transmembrane movement of substances
GO:0044325 ion channel binding
Biological Process
GO:0006200 ATP catabolic process
GO:0006810 transport
GO:0006813 potassium ion transport
GO:0007165 signal transduction
GO:0007268 synaptic transmission
GO:0010107 potassium ion import
GO:0051607 defense response to virus
GO:0055085 transmembrane transport
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0008076 voltage-gated potassium channel complex
GO:0008282 ATP-sensitive potassium channel complex
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030017 sarcomere
GO:0042383 sarcolemma
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030249
View Gene Order
ENSBTAG00000019294
Not yet available
Pathways
NETPATH
REACTOME
REACT_15480
ABC-family proteins mediated transport pathway
REACT_75775
ATP sensitive Potassium channels pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_13685
Neuronal System pathway
REACT_75918
Inwardly rectifying K+ channels pathway
REACT_75908
Potassium Channels pathway
KEGG
hsa02010
ABC transporters pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.446050 Hs.619371 Hs.631170 Hs.732701
RefSeq NM_005691 NM_020297 XM_005253284 XM_005253286 XM_005253287 XM_005253288
HUGO
OMIM
CCDS CCDS8693 CCDS8694
HPRD 03258
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca