Version 5.4
Homo sapiens Gene: TTPA
Summary
InnateDB Gene IDBG-23386.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TTPA
Gene Name tocopherol (alpha) transfer protein
Synonyms alphaTTP; ATTP; AVED; TTP1
Species Homo sapiens
Ensembl Gene ENSG00000137561
Encoded Proteins
IDBP-23388
tocopherol (alpha) transfer protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a soluble protein that binds alpha-trocopherol, a form of vitamin E, with high selectivity and affinity. This protein plays an important role in regulating vitamin E levels in the body by transporting vitamin E between membrane vesicles and facilitating the secretion of vitamin E from hepatocytes to circulating lipoproteins. Mutations in this gene cause hereditary vitamin E deficiency (ataxia with vitamin E deficiency, AVED) and retinitis pigmentosa. [provided by RefSeq, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:63048553-63086053
Strand Reverse strand
Band q12.3
Transcripts
ENST00000260116 ENSP00000260116
ENST00000521138
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0008431 vitamin E binding
GO:0019842 vitamin binding
GO:0043325 phosphatidylinositol-3,4-bisphosphate binding
Biological Process
GO:0001890 placenta development
GO:0001892 embryonic placenta development
GO:0006629 lipid metabolic process
GO:0006810 transport
GO:0007584 response to nutrient
GO:0009268 response to pH
GO:0009636 response to toxic substance
GO:0032502 developmental process
GO:0042360 vitamin E metabolic process
GO:0046909 intermembrane transport
GO:0051180 vitamin transport
GO:0051452 intracellular pH reduction
GO:0060548 negative regulation of cell death
GO:0090212 negative regulation of establishment of blood-brain barrier
Cellular Component
GO:0005770 late endosome
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000073988
View Gene Order
ENSBTAG00000022471
Not yet available
Cross-References
SwissProt P49638
TrEMBL
UniProt Splice Variant
Entrez Gene 7274
UniGene Hs.69049
RefSeq NM_000370
HUGO HGNC:12404
OMIM 600415
CCDS CCDS6178
HPRD
IMGT
EMBL AH006950 BC058000 D49488 U21938
GenPept AAA64309 AAC67490 AAH58000 BAA08449
RNA Seq Atlas 7274

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca