Version 5.4
Bos taurus Gene: TTPA
Summary
InnateDB Gene IDBG-644547.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TTPA
Gene Name alpha-tocopherol transfer protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000022471
Encoded Proteins
IDBP-697194
Uncharacterized protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000137561:
This gene encodes a soluble protein that binds alpha-trocopherol, a form of vitamin E, with high selectivity and affinity. This protein plays an important role in regulating vitamin E levels in the body by transporting vitamin E between membrane vesicles and facilitating the secretion of vitamin E from hepatocytes to circulating lipoproteins. Mutations in this gene cause hereditary vitamin E deficiency (ataxia with vitamin E deficiency, AVED) and retinitis pigmentosa. [provided by RefSeq, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:29765171-29793700
Strand Reverse strand
Band
Transcripts
ENSBTAT00000030426 ENSBTAP00000030408
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0043325 phosphatidylinositol-3,4-bisphosphate binding
Biological Process
GO:0001890 placenta development
GO:0001892 embryonic placenta development
GO:0006810 transport
GO:0009636 response to toxic substance
GO:0042360 vitamin E metabolic process
GO:0046909 intermembrane transport
GO:0051180 vitamin transport
GO:0090212 negative regulation of establishment of blood-brain barrier
Cellular Component
GO:0005622 intracellular
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000137561
View Gene Order
ENSMUSG00000073988
View Gene Order
Cross-References
SwissProt
TrEMBL F1N086 Q9TTZ2
UniProt Splice Variant
Entrez Gene 286813
UniGene Bt.42878
RefSeq NM_001206676
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF185291 DAAA02038418 DAAA02038419 DAAA02038420 DAAA02038421
GenPept AAD56583
RNA Seq Atlas 286813

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca