Version 5.4
Homo sapiens Gene: CD209
Summary
InnateDB Gene IDBG-23414.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD209
Gene Name CD209 molecule
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000090659
Encoded Proteins
IDBP-23416
CD209 molecule
IDBP-23418
CD209 molecule
IDBP-23420
CD209 molecule
IDBP-23424
CD209 molecule
IDBP-242086
CD209 molecule
IDBP-242088
CD209 molecule
IDBP-762920
IDBP-765792
IDBP-763392
IDBP-762689
IDBP-764282
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 18998127
CD209, upon pathogen binding, induces an intracellular signalling pathway with a central role for the serine/threonine kinase RAF1 and modulates TLR-induced activation.
PMID 22396536
CD209 is involved in cell-cell contact signalling between activated apoptotic lymphocytes and dendritic cells (DC) during the maturation of DCs.
Entrez Gene
Summary This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 10332; often referred to as L-SIGN). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.[provided by RefSeq, Feb 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:7739994-7747564
Strand Reverse strand
Band p13.2
Transcripts
ENST00000315599 ENSP00000315477
ENST00000315591 ENSP00000315407
ENST00000204801 ENSP00000204801
ENST00000354397 ENSP00000346373
ENST00000394173 ENSP00000377728
ENST00000394161 ENSP00000377716
ENST00000593821 ENSP00000471348
ENST00000593660 ENSP00000470530
ENST00000602261 ENSP00000471137
ENST00000601256 ENSP00000470658
ENST00000601951 ENSP00000468827
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 10 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005537 mannose binding
GO:0030246 carbohydrate binding
GO:0042605 peptide antigen binding
GO:0046790 virion binding
GO:0046872 metal ion binding
Biological Process
GO:0006897 endocytosis
GO:0007157 heterophilic cell-cell adhesion
GO:0007159 leukocyte cell-cell adhesion
GO:0009988 cell-cell recognition
GO:0019048 modulation by virus of host morphology or physiology
GO:0019062 virion attachment to host cell
GO:0019079 viral genome replication
GO:0019882 antigen processing and presentation
GO:0035556 intracellular signal transduction
GO:0042129 regulation of T cell proliferation
GO:0045087 innate immune response (InnateDB)
GO:0046968 peptide antigen transport
GO:0075733 intracellular transport of virus
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000065987
View Gene Order
Pathways
NETPATH
REACTOME
KEGG
hsa04145
Phagosome pathway
INOH
PID NCI
Cross-References
SwissProt Q9NNX6
TrEMBL
UniProt Splice Variant
Entrez Gene 30835
UniGene Hs.278694
RefSeq NM_001144897 NM_001144893 NM_001144894 NM_001144895 NM_001144896 NM_001144899 NM_021155
HUGO HGNC:1641
OMIM 604672
CCDS CCDS45951 CCDS12186 CCDS45949 CCDS45950 CCDS45952 CCDS59344 CCDS59345
HPRD 05241
IMGT
EMBL AC008763 AC008812 AF209479 AF290886 AK293089 AY042221 AY042222 AY042223 AY042224 AY042225 AY042226 AY042227 AY042228 AY042229 AY042230 AY042231 AY042232 AY042233 BC110615 CH471139 M98457
GenPept AAF77072 AAG13814 AAI10616 AAK20997 AAK91846 AAK91847 AAK91848 AAK91849 AAK91850 AAK91851 AAK91852 AAK91853 AAK91854 AAK91855 AAK91856 AAK91857 AAK91858 BAF85778 EAW68991 EAW68993 EAW68997 EAW68998
RNA Seq Atlas 30835

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca