|Mus musculus Gene: Cd209b|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||CD209b antigen|
|Synonyms||1810030I22Rik; DC-SIGNR1; mSIGNR1; OtB7; SIGNR1|
|Useful resources||Stemformatics EHFPI ImmGen|
|InnateDB Annotation from Orthologs|
[Homo sapiens] CD209, upon pathogen binding, induces an intracellular signalling pathway with a central role for the serine/threonine kinase RAF1 and modulates TLR-induced activation.
[Homo sapiens] CD209 is involved in cell-cell contact signalling between activated apoptotic lymphocytes and dendritic cells (DC) during the maturation of DCs.
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000090659:
This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 10332; often referred to as L-SIGN). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.[provided by RefSeq, Feb 2009]
|Genomic Location||Chromosome 8:3917655-3926844|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
|Pathway Predictions based on Human Orthology Data|
|UniProt Splice Variant|
|RefSeq||NM_001037800 NM_001287211 NM_026972|
|CCDS||CCDS22076 CCDS22077 CCDS72089|
|RNA Seq Atlas|