Version 5.4
Mus musculus Gene: Cd209b
Summary
InnateDB Gene IDBG-130726.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cd209b
Gene Name CD209b antigen
Synonyms 1810030I22Rik; DC-SIGNR1; mSIGNR1; OtB7; SIGNR1
Species Mus musculus
Ensembl Gene ENSMUSG00000065987
Encoded Proteins
IDBP-130728
CD209b antigen
IDBP-259003
CD209b antigen
IDBP-625359
CD209b antigen
IDBP-788964
CD209b antigen
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 18998127
[Homo sapiens] CD209, upon pathogen binding, induces an intracellular signalling pathway with a central role for the serine/threonine kinase RAF1 and modulates TLR-induced activation.
PMID 22396536
[Homo sapiens] CD209 is involved in cell-cell contact signalling between activated apoptotic lymphocytes and dendritic cells (DC) during the maturation of DCs.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000090659:
This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 10332; often referred to as L-SIGN). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.[provided by RefSeq, Feb 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:3917655-3926844
Strand Reverse strand
Band A1.1
Transcripts
ENSMUST00000084086 ENSMUSP00000081104
ENSMUST00000111014 ENSMUSP00000106643
ENSMUST00000171635 ENSMUSP00000126070
ENSMUST00000188386 ENSMUSP00000140695
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001872 (1->3)-beta-D-glucan binding
GO:0005537 mannose binding
GO:0030246 carbohydrate binding
GO:0030247 polysaccharide binding
GO:0046872 metal ion binding
Biological Process
GO:0001879 detection of yeast
GO:0006897 endocytosis
GO:0006910 phagocytosis, recognition
GO:0016045 detection of bacterium
GO:0042535 positive regulation of tumor necrosis factor biosynthetic process
GO:0050766 positive regulation of phagocytosis
Cellular Component
GO:0009897 external side of plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000090659
View Gene Order
Pathways
NETPATH
REACTOME
KEGG
mmu04145
Phagosome pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04145
Phagosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.175163
RefSeq NM_001037800 NM_001287211 NM_026972
OMIM
CCDS CCDS22076 CCDS22077 CCDS72089
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca