Version 5.4
Homo sapiens Gene: SH2B1
Summary
InnateDB Gene IDBG-23518.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SH2B1
Gene Name SH2B adaptor protein 1
Synonyms PSM; SH2B
Species Homo sapiens
Ensembl Gene ENSG00000178188
Encoded Proteins
IDBP-23520
SH2B adaptor protein 1
IDBP-23522
SH2B adaptor protein 1
IDBP-23524
SH2B adaptor protein 1
IDBP-239366
SH2B adaptor protein 1
IDBP-604202
SH2B adaptor protein 1
IDBP-604203
SH2B adaptor protein 1
IDBP-744956
IDBP-748588
IDBP-753906
IDBP-746676
IDBP-754006
IDBP-750956
IDBP-746870
IDBP-810001
SH2B adaptor protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the SH2-domain containing mediators family. The encoded protein mediates activation of various kinases and may function in cytokine and growth factor receptor signaling and cellular transformation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:28846600-28874212
Strand Forward strand
Band p11.2
Transcripts
ENST00000359285 ENSP00000352232
ENST00000337120 ENSP00000337163
ENST00000322610 ENSP00000321221
ENST00000395532 ENSP00000378903
ENST00000545570 ENSP00000440354
ENST00000538342 ENSP00000438784
ENST00000569651 ENSP00000457724
ENST00000567536 ENSP00000455236
ENST00000561629 ENSP00000454601
ENST00000566209 ENSP00000457214
ENST00000563674
ENST00000566176 ENSP00000455534
ENST00000569471
ENST00000568868 ENSP00000457315
ENST00000563591 ENSP00000458097
ENST00000618521 ENSP00000481709
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 23 [view]
Protein-Protein 23 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005515 protein binding
Biological Process
GO:0006928 cellular component movement
GO:0007596 blood coagulation
GO:0030032 lamellipodium assembly
GO:0035556 intracellular signal transduction
GO:0045840 positive regulation of mitosis
GO:2000278 regulation of DNA biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030733
View Gene Order
ENSBTAG00000019219
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
NetPath_22
Leptin pathway
NetPath_56
Prolactin pathway
REACTOME
REACT_24970
Factors involved in megakaryocyte development and platelet production pathway
REACT_604
Hemostasis pathway
KEGG
hsa04722
Neurotrophin signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt Q9NRF2
TrEMBL A0A024QZC2 B4DLN5 H3BTK4 H3BVF6
UniProt Splice Variant
Entrez Gene 25970
UniGene Hs.15744
RefSeq NM_001145795 NM_001145796 NM_001145797 NM_001145812 NM_015503 XM_006721031 XM_006721032 XM_006721033 XM_006721034
HUGO HGNC:30417
OMIM 608937
CCDS CCDS32424 CCDS53996 CCDS53997
HPRD 12336
IMGT
EMBL AB037720 AC133550 AF227967 AF227968 AF227969 AK027488 AK290332 AK297080 AL049924 AL713760 BC010704 CH471267
GenPept AAF73912 AAF73913 AAF73914 AAH10704 BAA92537 BAB55148 BAF83021 BAG59597 CAB43208 CAD28530 EAW52000 EAW52004
RNA Seq Atlas 25970

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca