InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: HTR1A

Summary

InnateDB Gene

IDBG-23546.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HTR1A

Gene Name

5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled

Synonyms

5-HT-1A; 5-HT1A; 5HT1a; ADRB2RL1; ADRBRL1; G-21; PFMCD

Species

Homo sapiens

Ensembl Gene

ENSG00000178394

Encoded Proteins

IDBP-23548

5-hydroxytryptamine (serotonin) receptor 1A

IDBP-481879

5-hydroxytryptamine (serotonin) receptor 1A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a G protein-coupled receptor for 5-hydroxytryptamine (serotonin), and belongs to the 5-hydroxytryptamine receptor subfamily. Serotonin has been implicated in a number of physiologic processes and pathologic conditions. Inactivation of this gene in mice results in behavior consistent with an increased anxiety and stress response. Mutation in the promoter of this gene has been associated with menstrual cycle-dependent periodic fevers. [provided by RefSeq, Jun 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:63960356-63962507

Strand

Reverse strand

Band

q12.3

Transcripts

ENST00000323865	ENSP00000316244
ENST00000506598	ENSP00000423433

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004993	serotonin receptor activity
GO:0005515	protein binding

Biological Process

GO:0001662	behavioral fear response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007198	adenylate cyclase-inhibiting serotonin receptor signaling pathway
GO:0007210	serotonin receptor signaling pathway
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0014062	regulation of serotonin secretion
GO:0035640	exploration behavior
GO:0042053	regulation of dopamine metabolic process
GO:0042310	vasoconstriction
GO:0042428	serotonin metabolic process
GO:0046883	regulation of hormone secretion
GO:0050795	regulation of behavior

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000021721

View Gene Order

ENSBTAG00000040439

Not yet available

Pathways

NETPATH

REACTOME

REACT_19231

G alpha (i) signalling events pathway

REACT_17064

Serotonin receptors pathway

REACT_16983

Amine ligand-binding receptors pathway

REACT_14828

Class A/1 (Rhodopsin-like receptors) pathway

REACT_14797

Signaling by GPCR pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

REACT_21340

GPCR ligand binding pathway

KEGG

hsa04080

Neuroactive ligand-receptor interaction pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

D6RA34

UniProt Splice Variant

Entrez Gene

3350

UniGene

Hs.247940 Hs.742469

RefSeq

NM_000524

HUGO

HGNC:5286

OMIM

109760

CCDS

CCDS34168

HPRD

00190

IMGT

EMBL

AC122707

GenPept

RNA Seq Atlas

3350