Homo sapiens Gene: HTR1A
Summary
InnateDB Gene IDBG-23546.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HTR1A
Gene Name 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
Synonyms 5-HT-1A; 5-HT1A; 5HT1a; ADRB2RL1; ADRBRL1; G-21; PFMCD;
Species Homo sapiens
Ensembl Gene ENSG00000178394
Encoded Proteins
5-hydroxytryptamine (serotonin) receptor 1A
5-hydroxytryptamine (serotonin) receptor 1A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a G protein-coupled receptor for 5-hydroxytryptamine (serotonin), and belongs to the 5-hydroxytryptamine receptor subfamily. Serotonin has been implicated in a number of physiologic processes and pathologic conditions. Inactivation of this gene in mice results in behavior consistent with an increased anxiety and stress response. Mutation in the promoter of this gene has been associated with menstrual cycle-dependent periodic fevers. [provided by RefSeq, Jun 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:63960356-63962507
Strand Reverse strand
Band q12.3
Transcripts
ENST00000323865 ENSP00000316244
ENST00000506598 ENSP00000423433
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0004993 serotonin receptor activity
GO:0005515 protein binding
Biological Process
GO:0001662 behavioral fear response
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway
GO:0007210 serotonin receptor signaling pathway
GO:0008283 cell proliferation
GO:0008284 positive regulation of cell proliferation
GO:0014062 regulation of serotonin secretion
GO:0035640 exploration behavior
GO:0042053 regulation of dopamine metabolic process
GO:0042310 vasoconstriction
GO:0042428 serotonin metabolic process
GO:0046883 regulation of hormone secretion
GO:0050795 regulation of behavior
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Serotonin receptors pathway
Amine ligand-binding receptors pathway
Signal Transduction pathway
GPCR downstream signaling pathway
G alpha (i) signalling events pathway
GPCR ligand binding pathway
KEGG
Neuroactive ligand-receptor interaction pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P08908
TrEMBL D6RA34 Q5ZGX3
UniProt Splice Variant
Entrez Gene 3350
UniGene Hs.247940 Hs.742469
RefSeq NM_000524
HUGO HGNC:5286
OMIM 109760
CCDS CCDS34168
HPRD 00190
IMGT
EMBL AB041403 AC122707 AF498978 AJ781317 BC069159 BC136263 CH471137 M28269 M83181 X13556 X57829 Z11168
GenPept AAA36440 AAA66493 AAH69159 AAI36264 AAM21125 BAA94488 CAA31908 CAA40962 CAA77560 CAH03197 EAW51377
RNA Seq Atlas 3350