Version 5.4
Homo sapiens Gene: PDE7A
Summary
InnateDB Gene IDBG-23581.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PDE7A
Gene Name phosphodiesterase 7A
Synonyms HCP1; PDE7
Species Homo sapiens
Ensembl Gene ENSG00000205268
Encoded Proteins
IDBP-23583
phosphodiesterase 7A
IDBP-237062
phosphodiesterase 7A
IDBP-293594
phosphodiesterase 7A
IDBP-484716
phosphodiesterase 7A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE7 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:65717510-65842322
Strand Reverse strand
Band q13.1
Transcripts
ENST00000379419 ENSP00000368730
ENST00000396642 ENSP00000379881
ENST00000401827 ENSP00000385632
ENST00000522220
ENST00000518667
ENST00000519231
ENST00000523253 ENSP00000430262
ENST00000519626
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity
GO:0046872 metal ion binding
Biological Process
GO:0006198 cAMP catabolic process
GO:0007165 signal transduction
Cellular Component
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000069094
View Gene Order
ENSBTAG00000011614
Not yet available
Pathways
NETPATH
REACTOME
REACT_19327
G alpha (s) signalling events pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
KEGG
hsa00230
Purine metabolism pathway
INOH
INOH website
Purine nucleotides nucleosides metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.527119 Hs.728847
RefSeq NM_001242318 NM_002603
HUGO
OMIM
CCDS CCDS34901 CCDS56538
HPRD 01386
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca