Homo sapiens Gene: PDE7A
Summary
InnateDB Gene IDBG-23581.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PDE7A
Gene Name phosphodiesterase 7A
Synonyms HCP1; PDE7;
Species Homo sapiens
Ensembl Gene ENSG00000205268
Encoded Proteins
phosphodiesterase 7A
phosphodiesterase 7A
phosphodiesterase 7A
phosphodiesterase 7A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE7 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:65717510-65842322
Strand Reverse strand
Band q13.1
Transcripts
ENST00000379419 ENSP00000368730
ENST00000396642 ENSP00000379881
ENST00000401827 ENSP00000385632
ENST00000522220
ENST00000518667
ENST00000519231
ENST00000523253 ENSP00000430262
ENST00000519626
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity
GO:0046872 metal ion binding
Biological Process
GO:0006198 cAMP catabolic process
GO:0007165 signal transduction
Cellular Component
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
G alpha (s) signalling events pathway
Signaling by GPCR pathway
Signal Transduction pathway
GPCR downstream signaling pathway
KEGG
Purine metabolism pathway
INOH
Purine nucleotides nucleosides metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q13946
TrEMBL Q7Z7I0 Q86V65
UniProt Splice Variant
Entrez Gene 5150
UniGene Hs.527119 Hs.728847
RefSeq NM_001242318 NM_002603
HUGO HGNC:8791
OMIM 171885
CCDS CCDS34901 CCDS56538
HPRD 01386
IMGT
EMBL AC055822 AC100812 AF332652 AJ457788 AK290801 AK292680 AY266364 BC126360 L12052 U67932
GenPept AAA35644 AAB65772 AAI26361 AAK57640 AAP31236 BAF83490 BAF85369 CAD29836
RNA Seq Atlas 5150