Mus musculus Gene: Pde7a
Summary
InnateDB Gene IDBG-132472.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pde7a
Gene Name phosphodiesterase 7A
Synonyms AU015378; AW047537
Species Mus musculus
Ensembl Gene ENSMUSG00000069094
Encoded Proteins
phosphodiesterase 7A
phosphodiesterase 7A
phosphodiesterase 7A
phosphodiesterase 7A
phosphodiesterase 7A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000205268:
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE7 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:19223108-19311322
Strand Reverse strand
Band A2
Transcripts
ENSMUST00000091314 ENSMUSP00000088863
ENSMUST00000099195 ENSMUSP00000096800
ENSMUST00000121951 ENSMUSP00000113173
ENSMUST00000141621
ENSMUST00000139426
ENSMUST00000149081 ENSMUSP00000120420
ENSMUST00000148590
ENSMUST00000156652 ENSMUSP00000119685
ENSMUST00000129060
ENSMUST00000143120
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity
GO:0046872 metal ion binding
Biological Process
GO:0006198 cAMP catabolic process
GO:0007165 signal transduction
GO:0008152 metabolic process
Cellular Component
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
G alpha (s) signalling events pathway
GPCR downstream signaling pathway
Signaling by GPCR pathway
Signal Transduction pathway
KEGG
Purine metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
G alpha (s) signalling events pathway
Signaling by GPCR pathway
Signal Transduction pathway
GPCR downstream signaling pathway
KEGG
Purine metabolism pathway
INOH
Purine nucleotides nucleosides metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.355614 Mm.482314
RefSeq NM_001122759 NM_008802 XM_006535405 XM_006535407 XM_006535408
OMIM
CCDS CCDS38398 CCDS50871
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas