Homo sapiens Gene: PHLDA2
Summary
InnateDB Gene IDBG-23772.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PHLDA2
Gene Name pleckstrin homology-like domain, family A, member 2
Synonyms BRW1C; BWR1C; HLDA2; IPL; TSSC3;
Species Homo sapiens
Ensembl Gene ENSG00000181649
Encoded Proteins
pleckstrin homology-like domain, family A, member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is located in a cluster of imprinted genes on chromosome 11p15.5, which is considered to be an important tumor suppressor gene region. Alterations in this region may be associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene has been shown to be imprinted, with preferential expression from the maternal allele in placenta and liver. [provided by RefSeq, Oct 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:2928273-2929455
Strand Reverse strand
Band p15.4
Transcripts
ENST00000314222 ENSP00000319231
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0001890 placenta development
GO:0006915 apoptotic process
GO:0009887 organ morphogenesis
GO:0010468 regulation of gene expression
GO:0030334 regulation of cell migration
GO:0045995 regulation of embryonic development
GO:0070873 regulation of glycogen metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt Q53GA4
TrEMBL
UniProt Splice Variant
Entrez Gene 7262
UniGene
RefSeq NM_003311
HUGO HGNC:12385
OMIM 602131
CCDS CCDS7741
HPRD 03679
IMGT
EMBL AF001294 AF019953 AF035444 AK223027 BC005034 CR407664
GenPept AAB86680 AAC17458 AAC51912 AAH05034 BAD96747 CAG28592
RNA Seq Atlas 7262