Homo sapiens Gene: CD19
Summary
InnateDB Gene IDBG-23791.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD19
Gene Name CD19 molecule
Synonyms B4; CVID3;
Species Homo sapiens
Ensembl Gene ENSG00000177455
Encoded Proteins
CD19 molecule
CD19 molecule
CD19 molecule
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:28931939-28939346
Strand Forward strand
Band p11.2
Transcripts
ENST00000324662 ENSP00000313419
ENST00000538922 ENSP00000437940
ENST00000567368
ENST00000567541 ENSP00000456201
ENST00000565089
ENST00000566890
ENST00000611258 ENSP00000481090
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 19 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005057 receptor signaling protein activity
GO:0005515 protein binding
Biological Process
GO:0006968 cellular defense response
GO:0007166 cell surface receptor signaling pathway
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0045087 innate immune response
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0050776 regulation of immune response
GO:0050853 B cell receptor signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
BCR pathway
REACTOME
Signaling by FGFR in disease pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
PI3K/AKT activation pathway
Downstream signaling of activated FGFR pathway
PI-3K cascade pathway
PI3K events in ERBB2 signaling pathway
DAP12 signaling pathway
Signaling by EGFR pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
Innate Immune System pathway
Signaling by ERBB4 pathway
Signaling by SCF-KIT pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
Adaptive Immune System pathway
Immune System pathway
Downstream signal transduction pathway
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway
NGF signalling via TRKA from the plasma membrane pathway
PI3K/AKT Signaling in Cancer pathway
Signaling by FGFR pathway
PIP3 activates AKT signaling pathway
Signaling by PDGF pathway
Signaling by ERBB2 pathway
Signaling by the B Cell Receptor (BCR) pathway
GAB1 signalosome pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Disease pathway
PI3K events in ERBB4 signaling pathway
DAP12 interactions pathway
KEGG
Hematopoietic cell lineage pathway
B cell receptor signaling pathway pathway
Primary immunodeficiency pathway
INOH
B cell receptor signaling pathway
PID BIOCARTA
PID NCI
BCR signaling pathway
Cross-References
SwissProt
TrEMBL Q71UW0
UniProt Splice Variant
Entrez Gene 930
UniGene
RefSeq NM_001178098 NM_001770 XM_006721103
HUGO HGNC:1633
OMIM 107265
CCDS CCDS10644 CCDS53998
HPRD
IMGT
EMBL AF045018
GenPept AAD02340
RNA Seq Atlas 930