InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ATP6V1G2

Summary

InnateDB Gene

IDBG-238100.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP6V1G2

Gene Name

ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2

Synonyms

ATP6G; ATP6G2; NG38; VMA10

Species

Homo sapiens

Ensembl Gene

ENSG00000213760

Encoded Proteins

IDBP-77735

ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2

IDBP-77739

ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2

IDBP-371480

ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2

IDBP-478137

ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of three V1 domain G subunit proteins. This gene had previous gene symbols of ATP6G and ATP6G2. Alternatively spliced transcript variants encoding different isoforms have been described. Read-through transcription also exists between this gene and the downstream DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B (DDX39B) gene. [provided by RefSeq, Feb 2011]
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c\', c\'\', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of three V1 domain G subunit proteins. This gene had previous gene symbols of ATP6G and ATP6G2. Alternatively spliced transcript variants encoding different isoforms have been described. Read-through transcription also exists between this gene and the downstream DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B (DDX39B) gene. [provided by RefSeq, Feb 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:31544462-31548427

Strand

Reverse strand

Band

p21.33

Transcripts

ENST00000303892	ENSP00000302194
ENST00000376151	ENSP00000365321
ENST00000415099	ENSP00000390148
ENST00000483251	ENSP00000419698
ENST00000483170
ENST00000481998

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016820	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances

Biological Process

GO:0006879	cellular iron ion homeostasis
GO:0008286	insulin receptor signaling pathway
GO:0015992	proton transport
GO:0033572	transferrin transport
GO:0051701	interaction with host
GO:0055085	transmembrane transport
GO:0090382	phagosome maturation

Cellular Component

GO:0005829	cytosol
GO:0016471	vacuolar proton-transporting V-type ATPase complex
GO:0042470	melanosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000024403

View Gene Order

ENSBTAG00000014491

Not yet available

Pathways

NETPATH

REACTOME

REACT_25283

Transferrin endocytosis and recycling pathway

REACT_25060

Iron uptake and transport pathway

REACT_1109

Insulin receptor recycling pathway

REACT_498

Signaling by Insulin receptor pathway

REACT_121256

Phagosomal maturation (early endosomal stage) pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_111102

Signal Transduction pathway

REACT_121237

Latent infection of Homo sapiens with Mycobacterium tuberculosis pathway

REACT_116125

Disease pathway

KEGG

hsa05110

Vibrio cholerae infection pathway

hsa05120

Epithelial cell signaling in Helicobacter pylori infection pathway

hsa00190

Oxidative phosphorylation pathway

hsa04966

Collecting duct acid secretion pathway

hsa04145

Phagosome pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.249227

RefSeq

NM_001204078 NM_130463 NM_138282

HUGO

OMIM

CCDS

CCDS4698 CCDS4699 CCDS56413

HPRD

06030

IMGT

EMBL

GenPept

RNA Seq Atlas