InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ATP6V1G2

Summary

InnateDB Protein

IDBP-77735.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP6V1G2

Protein Name

ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2

Synonyms

ATP6G; ATP6G2; NG38; VMA10;

Species

Homo sapiens

Ensembl Protein

ENSP00000302194

InnateDB Gene

IDBG-238100 (ATP6V1G2)

Protein Structure

UniProt Annotation

Function

Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

Subcellular Localization

Melanosome {ECO:0000269PubMed:17081065}. Note=Highly enriched in late-stage melanosomes.

Disease Associations

Tissue Specificity

Brain. {ECO:0000269PubMed:12384298}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016820	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances

Biological Process

GO:0006879	cellular iron ion homeostasis
GO:0008286	insulin receptor signaling pathway
GO:0015992	proton transport
GO:0033572	transferrin transport
GO:0051701	interaction with host
GO:0055085	transmembrane transport
GO:0090382	phagosome maturation