Homo sapiens Gene: MAGI2
Summary
InnateDB Gene IDBG-23858.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAGI2
Gene Name membrane associated guanylate kinase, WW and PDZ domain containing 2
Synonyms ACVRIP1; AIP-1; AIP1; ARIP1; MAGI-2; SSCAM;
Species Homo sapiens
Ensembl Gene ENSG00000187391
Encoded Proteins
membrane associated guanylate kinase, WW and PDZ domain containing 2
membrane associated guanylate kinase, WW and PDZ domain containing 2
membrane associated guanylate kinase, WW and PDZ domain containing 2
membrane associated guanylate kinase, WW and PDZ domain containing 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene interacts with atrophin-1. Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. This encoded protein is characterized by two WW domains, a guanylate kinase-like domain, and multiple PDZ domains. It has structural similarity to the membrane-associated guanylate kinase homologue (MAGUK) family. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:78017057-79453574
Strand Reverse strand
Band q21.11
Transcripts
ENST00000354212 ENSP00000346151
ENST00000419488 ENSP00000405766
ENST00000522391 ENSP00000428389
ENST00000519748
ENST00000522342
ENST00000524268
ENST00000524316
ENST00000520379
ENST00000517762
ENST00000535697 ENSP00000441603
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 14 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0019902 phosphatase binding
GO:0030159 receptor signaling complex scaffold activity
GO:0031697 beta-1 adrenergic receptor binding
GO:0046332 SMAD binding
GO:0070699 type II activin receptor binding
Biological Process
GO:0002092 positive regulation of receptor internalization
GO:0003402 planar cell polarity pathway involved in axis elongation
GO:0007165 signal transduction
GO:0008285 negative regulation of cell proliferation
GO:0010976 positive regulation of neuron projection development
GO:0016482 cytoplasmic transport
GO:0030336 negative regulation of cell migration
GO:0032516 positive regulation of phosphoprotein phosphatase activity
GO:0032926 negative regulation of activin receptor signaling pathway
GO:0038180 nerve growth factor signaling pathway
GO:0043113 receptor clustering
GO:0051291 protein heterooligomerization
GO:0051898 negative regulation of protein kinase B signaling
GO:0060395 SMAD protein signal transduction
GO:0071850 mitotic cell cycle arrest
GO:0072015 glomerular visceral epithelial cell development
GO:1990090 cellular response to nerve growth factor stimulus
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005770 late endosome
GO:0005886 plasma membrane
GO:0005923 tight junction
GO:0014069 postsynaptic density
GO:0030425 dendrite
GO:0036057 slit diaphragm
GO:0043234 protein complex
GO:0045202 synapse
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
Cell-Cell communication pathway
Nephrin interactions pathway
KEGG
Tight junction pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.603842 Hs.614527 Hs.618664 Hs.715948
RefSeq NM_001301128 NM_012301 XM_005250725
HUGO
OMIM
CCDS CCDS5594 CCDS75623
HPRD 16212
IMGT
EMBL
GenPept
RNA Seq Atlas