Version 5.4
Homo sapiens Gene: MAGI2
Summary
InnateDB Gene IDBG-23858.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAGI2
Gene Name membrane associated guanylate kinase, WW and PDZ domain containing 2
Synonyms ACVRIP1; AIP-1; AIP1; ARIP1; MAGI-2; SSCAM;
Species Homo sapiens
Ensembl Gene ENSG00000187391
Encoded Proteins
IDBP-23862
membrane associated guanylate kinase, WW and PDZ domain containing 2
IDBP-380231
membrane associated guanylate kinase, WW and PDZ domain containing 2
IDBP-475504
membrane associated guanylate kinase, WW and PDZ domain containing 2
IDBP-603296
membrane associated guanylate kinase, WW and PDZ domain containing 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene interacts with atrophin-1. Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. This encoded protein is characterized by two WW domains, a guanylate kinase-like domain, and multiple PDZ domains. It has structural similarity to the membrane-associated guanylate kinase homologue (MAGUK) family. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:78017057-79453574
Strand Reverse strand
Band q21.11
Transcripts
ENST00000354212 ENSP00000346151
ENST00000419488 ENSP00000405766
ENST00000522391 ENSP00000428389
ENST00000519748
ENST00000522342
ENST00000524268
ENST00000524316
ENST00000520379
ENST00000517762
ENST00000535697 ENSP00000441603
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 14 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0019902 phosphatase binding
GO:0030159 receptor signaling complex scaffold activity
GO:0031697 beta-1 adrenergic receptor binding
GO:0046332 SMAD binding
GO:0070699 type II activin receptor binding
Biological Process
GO:0002092 positive regulation of receptor internalization
GO:0003402 planar cell polarity pathway involved in axis elongation
GO:0007165 signal transduction
GO:0008285 negative regulation of cell proliferation
GO:0010976 positive regulation of neuron projection development
GO:0016482 cytoplasmic transport
GO:0030336 negative regulation of cell migration
GO:0032516 positive regulation of phosphoprotein phosphatase activity
GO:0032926 negative regulation of activin receptor signaling pathway
GO:0038180 nerve growth factor signaling pathway
GO:0043113 receptor clustering
GO:0051291 protein heterooligomerization
GO:0051898 negative regulation of protein kinase B signaling
GO:0060395 SMAD protein signal transduction
GO:0071850 mitotic cell cycle arrest
GO:0072015 glomerular visceral epithelial cell development
GO:1990090 cellular response to nerve growth factor stimulus
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005770 late endosome
GO:0005886 plasma membrane
GO:0005923 tight junction
GO:0014069 postsynaptic density
GO:0030425 dendrite
GO:0036057 slit diaphragm
GO:0043234 protein complex
GO:0045202 synapse
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
ENSMUSG00000040003
View Gene Order
RBBH
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
REACT_111155
Cell-Cell communication pathway
REACT_23832
Nephrin interactions pathway
KEGG
hsa04530
Tight junction pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.603842 Hs.614527 Hs.618664 Hs.715948
RefSeq NM_001301128 NM_012301 XM_005250725
HUGO
OMIM
CCDS CCDS5594 CCDS75623
HPRD 16212
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca