InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MAGI2

Summary

InnateDB Protein

IDBP-380231.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAGI2

Protein Name

membrane associated guanylate kinase, WW and PDZ domain containing 2

Synonyms

ACVRIP1; AIP-1; AIP1; ARIP1; MAGI-2; SSCAM;

Species

Homo sapiens

Ensembl Protein

ENSP00000405766

InnateDB Gene

IDBG-23858 (MAGI2)

Protein Structure

UniProt Annotation

Function

Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. {ECO:0000269PubMed:10760291}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Late endosome {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Localized diffusely in the cytoplasm before nerve growth factor (NGF) stimulation. Recruted to late endosomes after NGF stimulation. Membrane-associated in synaptosomes (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Specifically expressed in brain. {ECO:0000269PubMed:9647693}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	14 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019902	phosphatase binding
GO:0030159	receptor signaling complex scaffold activity
GO:0031697	beta-1 adrenergic receptor binding
GO:0046332	SMAD binding
GO:0070699	type II activin receptor binding

Biological Process

GO:0002092	positive regulation of receptor internalization
GO:0003402	planar cell polarity pathway involved in axis elongation
GO:0008285	negative regulation of cell proliferation
GO:0010976	positive regulation of neuron projection development
GO:0016482	cytoplasmic transport
GO:0030336	negative regulation of cell migration
GO:0032516	positive regulation of phosphoprotein phosphatase activity
GO:0032926	negative regulation of activin receptor signaling pathway
GO:0038180	nerve growth factor signaling pathway
GO:0043113	receptor clustering
GO:0051291	protein heterooligomerization
GO:0051898	negative regulation of protein kinase B signaling
GO:0060395	SMAD protein signal transduction
GO:0071850	mitotic cell cycle arrest
GO:0072015	glomerular visceral epithelial cell development
GO:1990090	cellular response to nerve growth factor stimulus

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005770	late endosome
GO:0005886	plasma membrane
GO:0005923	tight junction
GO:0014069	postsynaptic density
GO:0030425	dendrite
GO:0036057	slit diaphragm
GO:0043234	protein complex
GO:0045202	synapse
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR001202 WW domain
IPR001478 PDZ domain
IPR008144 Guanylate kinase-like
IPR008145 Guanylate kinase/L-type calcium channel beta subunit
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00397
PF00595
PF13180
PF00625

PRINTS

PIRSF

SMART

SM00456
SM00228
SM00072

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q86UL8