Homo sapiens Gene: S1PR3
Summary
InnateDB Gene IDBG-239062.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol S1PR3
Gene Name sphingosine-1-phosphate receptor 3
Synonyms EDG-3; EDG3; LPB3; S1P3;
Species Homo sapiens
Ensembl Gene ENSG00000213694
Encoded Proteins
sphingosine-1-phosphate receptor 3
sphingosine-1-phosphate receptor 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the EDG family of receptors, which are G protein-coupled receptors. This protein has been identified as a functional receptor for sphingosine 1-phosphate and likely contributes to the regulation of angiogenesis and vascular endothelial cell function. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:88991447-89005010
Strand Forward strand
Band q22.1
Transcripts
ENST00000358157 ENSP00000350878
ENST00000375846 ENSP00000365006
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0005178 integrin binding
GO:0008289 lipid binding
GO:0038036 sphingosine-1-phosphate receptor activity
Biological Process
GO:0001816 cytokine production
GO:0003376 sphingosine-1-phosphate signaling pathway
GO:0006954 inflammatory response
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0008284 positive regulation of cell proliferation
GO:0009653 anatomical structure morphogenesis
GO:0032651 regulation of interleukin-1 beta production
GO:1903141 negative regulation of establishment of endothelial barrier
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Lysosphingolipid and LPA receptors pathway
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Signal Transduction pathway
GPCR downstream signaling pathway
G alpha (i) signalling events pathway
GPCR ligand binding pathway
KEGG
Neuroactive ligand-receptor interaction pathway
INOH
PID BIOCARTA
PID NCI
Sphingosine 1-phosphate (S1P) pathway
S1P3 pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.585118 Hs.737182
RefSeq NM_005226
HUGO
OMIM
CCDS CCDS6680
HPRD 03572
IMGT
EMBL
GenPept
RNA Seq Atlas