Homo sapiens Gene: SULT1A4
Summary
InnateDB Gene IDBG-239592.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SULT1A4
Gene Name sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000213648
Encoded Proteins
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a phenol sulfotransferase with thermolabile enzyme activity. Four sulfotransferase genes are located on the p arm of chromosome 16, this gene and SULT1A3 arose from a segmental duplication. Read-through transcription exists between this gene and the upstream SLX1B (SLX1 structure-specific endonuclease subunit homolog B) gene that encodes a protein containing GIY-YIG domains. [provided by RefSeq, Nov 2010] Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a phenol sulfotransferase with thermolabile enzyme activity. Four sulfotransferase genes are located on the p arm of chromosome 16; this gene and SULT1A4 arose from a segmental duplication. This gene is the most centromeric of the four sulfotransferase genes. Read-through transcription exists between this gene and the upstream SLX1A (SLX1 structure-specific endonuclease subunit homolog A) gene that encodes a protein containing GIY-YIG domains. [provided by RefSeq, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:29459889-29464976
Strand Forward strand
Band p11.2
Transcripts
ENST00000344620
ENST00000360423 ENSP00000353600
ENST00000395400
ENST00000562941
ENST00000565290 ENSP00000456834
ENST00000569544 ENSP00000455063
ENST00000563944 ENSP00000457597
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004062 aryl sulfotransferase activity
GO:0008146 sulfotransferase activity
Biological Process
GO:0006584 catecholamine metabolic process
GO:0006805 xenobiotic metabolic process
GO:0006987 activation of signaling protein activity involved in unfolded protein response
GO:0008152 metabolic process
GO:0008202 steroid metabolic process
GO:0009812 flavonoid metabolic process
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0044267 cellular protein metabolic process
GO:0044281 small molecule metabolic process
GO:0050427 3'-phosphoadenosine 5'-phosphosulfate metabolic process
GO:0051923 sulfation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
IRE1alpha activates chaperones pathway
Unfolded Protein Response (UPR) pathway
XBP1(S) activates chaperone genes pathway
Metabolism of proteins pathway
Phase II conjugation pathway
Metabolism pathway
Cytosolic sulfonation of small molecules pathway
Biological oxidations pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P50224
TrEMBL H3BNY7 Q1ET61 Q9UMT9
UniProt Splice Variant
Entrez Gene 6818
UniGene
RefSeq NM_001017390 XM_005276507 XM_006726621
HUGO HGNC:30004
OMIM 600641 615819
CCDS CCDS32427
HPRD
IMGT
EMBL AB111093 AB111094 AB111099 AC106782 AC133555 AK122707 AK122733 AK298073 BC014471 BC078144 BC132914 BC132920 BC144354 BC144355 BC171772 L19956 L25275 L34160 U08032 U08099 U20499 U34199 U37025 U37686 X84653
GenPept AAA02943 AAA17723 AAA36523 AAA64490 AAA82126 AAA86536 AAB09759 AAC99987 AAH14471 AAH78144 AAI32915 AAI32921 AAI44355 AAI44356 AAI71772 BAC85507 BAE94927 BAE94928 BAE94933 BAG53679 BAG60362 CAA59146
RNA Seq Atlas 101929857 445329 6818