InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SULT1A4

Summary

InnateDB Protein

IDBP-24278.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SULT1A4

Protein Name

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000353600

InnateDB Gene

IDBG-239592 (SULT1A4)

Protein Structure

UniProt Annotation

Function

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic monoamines (neurotransmitters such as dopamine, norepinephrine and serotonin) and phenolic and catechol drugs.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Liver, colon, kidney, lung, brain, spleen, small intestine, placenta and leukocyte.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004062	aryl sulfotransferase activity
GO:0008146	sulfotransferase activity

Biological Process

GO:0006584	catecholamine metabolic process
GO:0006805	xenobiotic metabolic process
GO:0006987	activation of signaling protein activity involved in unfolded protein response
GO:0008202	steroid metabolic process
GO:0009812	flavonoid metabolic process
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0044267	cellular protein metabolic process
GO:0044281	small molecule metabolic process
GO:0050427	3'-phosphoadenosine 5'-phosphosulfate metabolic process
GO:0051923	sulfation