Version 5.4
Homo sapiens Gene: ISL2
Summary
InnateDB Gene IDBG-23963.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ISL2
Gene Name ISL LIM homeobox 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000159556
Encoded Proteins
IDBP-23965
ISL LIM homeobox 2
IDBP-589928
ISL LIM homeobox 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 15:76336724-76342476
Strand Forward strand
Band q24.3
Transcripts
ENST00000290759 ENSP00000290759
ENST00000558656 ENSP00000453837
ENST00000558437
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0021520 spinal cord motor neuron cell fate specification
GO:0021524 visceral motor neuron differentiation
GO:0031290 retinal ganglion cell axon guidance
GO:0045665 negative regulation of neuron differentiation
GO:0048663 neuron fate commitment
GO:0048666 neuron development
GO:0048935 peripheral nervous system neuron development
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032318
View Gene Order
ENSBTAG00000016651
Not yet available
Cross-References
SwissProt
TrEMBL H0YN25
UniProt Splice Variant
Entrez Gene 64843
UniGene
RefSeq NM_145805
HUGO HGNC:18524
OMIM 609481
CCDS CCDS10290
HPRD 11053
IMGT
EMBL AC027243
GenPept
RNA Seq Atlas 64843

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca