InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ISL2

Summary

InnateDB Protein

IDBP-23965.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ISL2

Protein Name

ISL LIM homeobox 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000290759

InnateDB Gene

IDBG-23963 (ISL2)

Protein Structure

UniProt Annotation

Function

Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00108}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0021520	spinal cord motor neuron cell fate specification
GO:0021524	visceral motor neuron differentiation
GO:0031290	retinal ganglion cell axon guidance
GO:0045665	negative regulation of neuron differentiation
GO:0048663	neuron fate commitment
GO:0048666	neuron development
GO:0048935	peripheral nervous system neuron development