Homo sapiens Gene: CXCL1
Summary
InnateDB Gene IDBG-24070.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CXCL1
Gene Name chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
Synonyms FSP; GRO1; GROa; MGSA; MGSA-a; NAP-3; SCYB1;
Species Homo sapiens
Ensembl Gene ENSG00000163739
Encoded Proteins
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signal through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. Aberrant expression this protein is associated with the growth and progression of certain tumors. A naturally occurring processed form of this protein has increased chemotactic activity. Alternate splicing results in coding and non-coding variants of this gene. A pseudogene of this gene is found on chromosome 4. [provided by RefSeq, Jan 2012]
This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. Aberrant expression of this protein is associated with the growth and progression of certain tumors. A naturally occurring processed form of this protein has increased chemotactic activity. Alternate splicing results in coding and non-coding variants of this gene. A pseudogene of this gene is found on chromosome 4. [provided by RefSeq, Sep 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:73869393-73871242
Strand Forward strand
Band q13.3
Transcripts
ENST00000395761 ENSP00000379110
ENST00000509101
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 15 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0008009 chemokine activity
GO:0008047 enzyme activator activity
GO:0008083 growth factor activity
Biological Process
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007399 nervous system development
GO:0008283 cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0030036 actin cytoskeleton organization
GO:0035556 intracellular signal transduction
GO:0043085 positive regulation of catalytic activity
GO:0060326 cell chemotaxis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Peptide ligand-binding receptors pathway
Chemokine receptors bind chemokines pathway
Signal Transduction pathway
GPCR downstream signaling pathway
G alpha (i) signalling events pathway
GPCR ligand binding pathway
KEGG
Cytokine-cytokine receptor interaction pathway
Chemokine signaling pathway pathway
NOD-like receptor signaling pathway pathway
Epithelial cell signaling in Helicobacter pylori infection pathway
Amoebiasis pathway
INOH
PID BIOCARTA
PID NCI
IL23-mediated signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.708652 Hs.789
RefSeq NM_001511
HUGO
OMIM
CCDS CCDS47074
HPRD 01119
IMGT
EMBL
GenPept
RNA Seq Atlas