Version 5.4
Homo sapiens Gene: CXCL1
Summary
InnateDB Gene IDBG-24070.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CXCL1
Gene Name chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
Synonyms FSP; GRO1; GROa; MGSA; MGSA-a; NAP-3; SCYB1
Species Homo sapiens
Ensembl Gene ENSG00000163739
Encoded Proteins
IDBP-238912
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signal through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. Aberrant expression this protein is associated with the growth and progression of certain tumors. A naturally occurring processed form of this protein has increased chemotactic activity. Alternate splicing results in coding and non-coding variants of this gene. A pseudogene of this gene is found on chromosome 4. [provided by RefSeq, Jan 2012]
This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. Aberrant expression of this protein is associated with the growth and progression of certain tumors. A naturally occurring processed form of this protein has increased chemotactic activity. Alternate splicing results in coding and non-coding variants of this gene. A pseudogene of this gene is found on chromosome 4. [provided by RefSeq, Sep 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:73869393-73871242
Strand Forward strand
Band q13.3
Transcripts
ENST00000395761 ENSP00000379110
ENST00000509101
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 15 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0008009 chemokine activity
GO:0008047 enzyme activator activity
GO:0008083 growth factor activity
Biological Process
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007399 nervous system development
GO:0008283 cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0030036 actin cytoskeleton organization
GO:0035556 intracellular signal transduction
GO:0043085 positive regulation of catalytic activity
GO:0060326 cell chemotaxis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_19231
G alpha (i) signalling events pathway
REACT_15344
Chemokine receptors bind chemokines pathway
REACT_14819
Peptide ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
KEGG
hsa05120
Epithelial cell signaling in Helicobacter pylori infection pathway
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04062
Chemokine signaling pathway pathway
hsa04621
NOD-like receptor signaling pathway pathway
hsa05146
Amoebiasis pathway
INOH
PID NCI
il23pathway
IL23-mediated signaling events
Cross-References
SwissProt P09341
TrEMBL Q6LD34
UniProt Splice Variant
Entrez Gene 2919
UniGene Hs.708652 Hs.789
RefSeq NM_001511
HUGO HGNC:4602
OMIM 155730
CCDS CCDS47074
HPRD 01119
IMGT
EMBL BC011976 BT006880 J03561 U03018 X12510 X54489
GenPept AAA03452 AAA35933 AAH11976 AAP35526 CAA31027 CAA38361
RNA Seq Atlas 2919

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca