Version 5.4
Homo sapiens Gene: ARL2
Summary
InnateDB Gene IDBG-241808.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARL2
Gene Name ADP-ribosylation factor-like 2
Synonyms ARFL2
Species Homo sapiens
Ensembl Gene ENSG00000213465
Encoded Proteins
IDBP-56096
ADP-ribosylation factor-like 2
IDBP-595868
ADP-ribosylation factor-like 2
IDBP-595363
ADP-ribosylation factor-like 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a small GTP-binding protein of the RAS superfamily which functions as an ADP-ribosylation factor (ARF). The encoded protein is one of a functionally distinct group of ARF-like genes. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:65014113-65022184
Strand Forward strand
Band q13.1
Transcripts
ENST00000246747 ENSP00000246747
ENST00000524585
ENST00000529384 ENSP00000436021
ENST00000533729 ENSP00000432971
ENST00000531533
ENST00000529254
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
Experimentally validated
Total 24 [view]
Protein-Protein 24 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0004871 signal transducer activity
GO:0005095 GTPase inhibitor activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0019001 guanyl nucleotide binding
GO:0019003 GDP binding
GO:0031683 G-protein beta/gamma-subunit complex binding
Biological Process
GO:0006184 GTP catabolic process
GO:0006886 intracellular protein transport
GO:0007021 tubulin complex assembly
GO:0007049 cell cycle
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0010811 positive regulation of cell-substrate adhesion
GO:0015031 protein transport
GO:0031113 regulation of microtubule polymerization
GO:0031116 positive regulation of microtubule polymerization
GO:0034260 negative regulation of GTPase activity
GO:0051297 centrosome organization
GO:0051457 maintenance of protein location in nucleus
GO:0070830 tight junction assembly
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005758 mitochondrial intermembrane space
GO:0005813 centrosome
GO:0016328 lateral plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024944
View Gene Order
ENSBTAG00000002238
Not yet available
Pathways
NETPATH
REACTOME
REACT_16967
Post-chaperonin tubulin folding pathway pathway
REACT_16952
Protein folding pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_267716
Orphan transporters pathway
REACT_17015
Metabolism of proteins pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001199745 NM_001667
HUGO
OMIM
CCDS CCDS55770 CCDS8088
HPRD 11869
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca