InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ARL2

Summary

InnateDB Protein

IDBP-595363.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARL2

Protein Name

ADP-ribosylation factor-like 2

Synonyms

ARFL2;

Species

Homo sapiens

Ensembl Protein

ENSP00000432971

InnateDB Gene

IDBG-241808 (ARL2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.

Experimentally validated
Total	24 [view]
Protein-Protein	24 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0004871	signal transducer activity
GO:0005095	GTPase inhibitor activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0019001	guanyl nucleotide binding
GO:0031683	G-protein beta/gamma-subunit complex binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006886	intracellular protein transport
GO:0007021	tubulin complex assembly
GO:0007049	cell cycle
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007264	small GTPase mediated signal transduction
GO:0010811	positive regulation of cell-substrate adhesion
GO:0031113	regulation of microtubule polymerization
GO:0031116	positive regulation of microtubule polymerization
GO:0034260	negative regulation of GTPase activity
GO:0051297	centrosome organization
GO:0051457	maintenance of protein location in nucleus
GO:0070830	tight junction assembly

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005758	mitochondrial intermembrane space
GO:0005813	centrosome
GO:0016328	lateral plasma membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
IPR001806 Small GTPase superfamily
IPR005225 Small GTP-binding protein domain
IPR006687 Small GTPase superfamily, SAR1-type
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR006762 Gtr1/RagA G protein
IPR013684 Mitochondrial Rho-like
IPR019009 Signal recognition particle receptor, beta subunit
IPR024156 Small GTPase superfamily, ARF type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00503
PF00071
PF00025
PF04670
PF08477
PF09439

PRINTS

PR00318
PR00449
PR00328

PIRSF

SMART

SM00275
SM00178
SM00177

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt