Version 5.4
| Homo sapiens Gene: CXCL5 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-24181.5 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | CXCL5 | ||||||||||||||||||
| Gene Name | chemokine (C-X-C motif) ligand 5 | ||||||||||||||||||
| Synonyms | ENA-78; SCYB5 | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000163735 | ||||||||||||||||||
| Encoded Proteins |
chemokine (C-X-C motif) ligand 5
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
The protein encoded by this gene is an inflammatory chemokine that belongs to the CXC chemokine family. This chemokine is produced concomitantly with interleukin-8 (IL8) in response to stimulation with either interleukin-1 (IL1) or tumor necrosis factor-alpha (TNFA). This chemokine is a potent chemotaxin involved in neutrophil activation. [provided by RefSeq, Jul 2008] This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils, to promote angiogenesis and to remodel connective tissues. This protein is thought to play a role in cancer cell proliferation, migration, and invasion. [provided by RefSeq, May 2013] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 4:73995642-73998779 | ||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||
| Band | q13.3 | ||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
| No orthologs found for this gene | |||||||||||||||||||
| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
G alpha (i) signalling events pathway
Chemokine receptors bind chemokines pathway
Peptide ligand-binding receptors pathway
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Signal Transduction pathway
GPCR downstream signaling pathway
GPCR ligand binding pathway
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| KEGG |
Cytokine-cytokine receptor interaction pathway
Chemokine signaling pathway pathway
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| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | P42830 | ||||||||||||||||||
| TrEMBL | Q6I9S7 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 6374 | ||||||||||||||||||
| UniGene | Hs.603888 Hs.89714 | ||||||||||||||||||
| RefSeq | NM_002994 | ||||||||||||||||||
| HUGO | HGNC:10642 | ||||||||||||||||||
| OMIM | 600324 | ||||||||||||||||||
| CCDS | CCDS34006 | ||||||||||||||||||
| HPRD | |||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AC097709 AF349466 AJ315732 AK312128 BC008376 BT006807 CH471057 CR457428 L37036 U12709 X78686 | ||||||||||||||||||
| GenPept | AAA62475 AAA86426 AAH08376 AAK29641 AAP35453 AAY41005 BAG35064 CAA55355 CAC42884 CAG33709 EAX05696 | ||||||||||||||||||
| RNA Seq Atlas | 6374 | ||||||||||||||||||